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2018-06-12Zeitschriftenartikel DOI: 10.25646/5693
High genomic diversity of multi-drug resistant wastewater Escherichia coli
dc.contributor.authorMahfouz, Norhan
dc.contributor.authorCaucci, Serena
dc.contributor.authorAchatz, Eric
dc.contributor.authorSemmler, Torsten
dc.contributor.authorGuenther, Sebastian
dc.contributor.authorBerendonk, Thomas U.
dc.contributor.authorSchroeder, Michael
dc.date.accessioned2018-09-18T13:02:49Z
dc.date.available2018-09-18T13:02:49Z
dc.date.issued2018-06-12none
dc.identifier.other10.1038/s41598-018-27292-6
dc.identifier.urihttp://edoc.rki.de/176904/5756
dc.description.abstractWastewater treatment plants play an important role in the emergence of antibiotic resistance. They provide a hot spot for exchange of resistance within and between species. Here, we analyse and quantify the genomic diversity of the indicator Escherichia coli in a German wastewater treatment plant and we relate it to isolates’ antibiotic resistance. Our results show a surprisingly large pan-genome, which mirrors how rich an environment a treatment plant is. We link the genomic analysis to a phenotypic resistance screen and pinpoint genomic hot spots, which correlate with a resistance phenotype. Besides well-known resistance genes, this forward genomics approach generates many novel genes, which correlated with resistance and which are partly completely unknown. A surprising overall finding of our analyses is that we do not see any difference in resistance and pan genome size between isolates taken from the inflow of the treatment plant and from the outflow. This means that while treatment plants reduce the amount of bacteria released into the environment, they do not reduce the potential for antibiotic resistance of these bacteria.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHigh genomic diversity of multi-drug resistant wastewater Escherichia colinone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5756-5
dc.identifier.doihttp://dx.doi.org/10.25646/5693
dc.type.versionpublishedVersionnone
local.edoc.container-titleScientific Reportsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameNature Publishing Groupnone
local.edoc.container-volume8none
local.edoc.container-issue8928none
local.edoc.container-reportyear2018none
local.edoc.container-yearhttps://www.nature.com/articles/s41598-018-27292-6none
local.edoc.container-firstpage1none
local.edoc.container-lastpage12none
local.edoc.rki-departmentProjektgruppen/Nachwuchsgruppennone
dc.description.versionPeer Reviewednone

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