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2010-02-11Zeitschriftenartikel DOI: 10.25646/511
Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8
dc.contributor.authorBuchholz, Udo
dc.contributor.authorBrockmann, Stefan
dc.contributor.authorDuwe, Susanne
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorHeiden, Matthias an der
dc.contributor.authorReinhardt, Bernd
dc.contributor.authorBuda, Silke
dc.date.accessioned2018-05-07T13:42:42Z
dc.date.available2018-05-07T13:42:42Z
dc.date.created2010-02-25
dc.date.issued2010-02-11none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reO7Yksi8IbO/PDF/29q2emGdyHCk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/586
dc.description.abstractDuring the influenza season 2007-8, the proportion of seasonal influenza A(H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. We conducted an investigation to compare patients infected with oseltamivir-resistant (ose-R) and oseltamivir- susceptible (ose-S) influenza A(H1N1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. Within a cohort of 396 laboratory confirmed influenza patients from sentinel physicians we conducted a nested casecontrol study among patients infected with A(H1N1). Thirty patients in the cohort were infected with influenza B, none with influenza A(H3N2) and 366 with A(H1N1). Of the 366 A(H1N1) viruses 52 (14%) were ose-R. Demographic characteristics, oseltamivir exposure, travel history and outcome were not significantly different between ose-S and ose-R patients. Among 133 households in the nested case-control study, secondary household attack rates in households with ose-R cases and households with ose-S cases were similar (23 versus 26%; p-value=0.54). Ose-R household status and occurrence of secondary cases were associated with an odds ratio of 0.85 (95% confidence interval 0.38-1.88). We conclude that seasonal ose-R influenza A(H1N1) viruses have transmitted well in the household setting.ger
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectHuman/epidemiologyeng
dc.subjectViraleng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectGermany/epidemiologyeng
dc.subjectMaleeng
dc.subjectIncidenceeng
dc.subjectRisk Factorseng
dc.subjectCohort Studieseng
dc.subjectRisk Assessmenteng
dc.subjectDrug Resistanceeng
dc.subjectInfluenza A Viruseng
dc.subjectInfluenzaeng
dc.subjectHuman/drug therapyeng
dc.subjectSeasonseng
dc.subjectDisease Outbreaks/statistics & numerical dataeng
dc.subjectH1N1 Subtypeeng
dc.subjectHuman/transmissioneng
dc.subjectAntiviral Agents/therapeutic useeng
dc.subjectHousing/statistics & numerical dataeng
dc.subjectOseltamivir/therapeutic useeng
dc.subject.ddc610 Medizin
dc.titleHousehold transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1005825
dc.identifier.doihttp://dx.doi.org/10.25646/511
local.edoc.container-titleEuroSurveillance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19483
local.edoc.container-publisher-nameECDC
local.edoc.container-volume15
local.edoc.container-issue6
local.edoc.container-year2010

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