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2019-01-09Zeitschriftenartikel DOI: 10.25646/5897
Respiratory Virus Infections in Hematopoietic Cell Transplant Recipients
dc.contributor.authorPochon, Cécile
dc.contributor.authorVoigt, Sebastian
dc.date.accessioned2019-02-20T10:14:50Z
dc.date.available2019-02-20T10:14:50Z
dc.date.issued2019-01-09none
dc.identifier.other10.3389/fmicb.2018.03294
dc.identifier.urihttp://edoc.rki.de/176904/5937
dc.description.abstractHighly immunocompromised pediatric and adult hematopoietic cell transplant (HCT) recipients frequently experience respiratory infections caused by viruses that are less virulent in immunocompetent individuals. Most of these infections, with the exception of rhinovirus as well as adenovirus and parainfluenza virus in tropical areas, are seasonal variable and occur before and after HCT. Infectious disease management includes sampling of respiratory specimens from nasopharyngeal washes or swabs as well as sputum and tracheal or tracheobronchial lavages. These are subjected to improved diagnostic tools including multiplex PCR assays that are routinely used allowing for expedient detection of all respiratory viruses. Disease progression along with high mortality is frequently associated with respiratory syncytial virus, parainfluenza virus, influenza virus, and metapneumovirus infections. In this review, we discuss clinical findings and the appropriate use of diagnostic measures. Additionally, we also discuss treatment options and suggest new drug formulations that might prove useful in treating respiratory viral infections. Finally, we shed light on the role of the state of immune reconstitution and on the use of immunosuppressive drugs on the outcome of infection.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectantiviral therapyeng
dc.subjectco-infectioneng
dc.subjecthematopoietic cell transplantationeng
dc.subjectimmunosuppressioneng
dc.subjectinfection outcomeeng
dc.subjectinvestigational drugseng
dc.subjectrespiratory virus infectioneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleRespiratory Virus Infections in Hematopoietic Cell Transplant Recipientsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5937-6
dc.identifier.doihttp://dx.doi.org/10.25646/5897
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in Microbiologynone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.frontiersin.org/articles/10.3389/fmicb.2018.03294/fullnone
local.edoc.container-publisher-nameFrontiers Medianone
local.edoc.container-volume9none
local.edoc.container-issue3294none
local.edoc.container-reportyear2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage17none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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