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2018-10-06Zeitschriftenartikel DOI: 10.25646/5920
Whole Genome Characterization of Orthopoxvirus (OPV) Abatino, a Zoonotic Virus Representing a Putative Novel Clade of Old World Orthopoxviruses
dc.contributor.authorGruber, Cesare E. M.
dc.contributor.authorGiombini, Emanuela
dc.contributor.authorSelleri, Marina
dc.contributor.authorTausch, Simon H.
dc.contributor.authorAndrusch, Andreas
dc.contributor.authorTyshaieva, Alona
dc.contributor.authorCardeti, Giusy
dc.contributor.authorLorenzetti, Raniero
dc.contributor.authorDe Marco, Lorenzo
dc.contributor.authorCarletti, Fabrizio
dc.contributor.authorNitsche, Andreas
dc.contributor.authorCapobianchi, Maria R.
dc.contributor.authorIppolito, Giuseppe
dc.contributor.authorAutorino, Gian Luca
dc.contributor.authorCastilletti, Concetta
dc.date.accessioned2019-03-05T07:10:40Z
dc.date.available2019-03-05T07:10:40Z
dc.date.issued2018-10-06none
dc.identifier.other10.3390/v10100546
dc.identifier.urihttp://edoc.rki.de/176904/5955
dc.description.abstractOrthopoxviruses (OPVs) are diffused over the complete Eurasian continent, but previously described strains are mostly from northern Europe, and few infections have been reported from Italy. Here we present the extended genomic characterization of OPV Abatino, a novel OPV isolated in Italy from an infected Tonkean macaque, with zoonotic potential. Phylogenetic analysis based on 102 conserved OPV genes (core gene set) showed that OPV Abatino is most closely related to the Ectromelia virus species (ECTV), although placed on a separate branch of the phylogenetic tree, bringing substantial support to the hypothesis that this strain may be part of a novel OPV clade. Extending the analysis to the entire set of genes (coding sequences, CDS) further substantiated this hypothesis. In fact the genome of OPV Abatino included more CDS than ECTV; most of the extra genes (mainly located in the terminal genome regions), showed the highest similarity with cowpox virus (CPXV); however vaccinia virus (VACV) and monkeypox virus (MPXV) were the closest OPV for certain CDS. These findings suggest that OPV Abatino could be the result of complex evolutionary events, diverging from any other previously described OPV, and may indicate that previously reported cases in Italy could represent the tip of the iceberg yet to be explored.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectOPV Abatinoeng
dc.subjectorthopoxviruseng
dc.subjectcowpox viruseng
dc.subjectectromelia viruseng
dc.subjectphylogenetic treeeng
dc.subjectcore gene seteng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleWhole Genome Characterization of Orthopoxvirus (OPV) Abatino, a Zoonotic Virus Representing a Putative Novel Clade of Old World Orthopoxvirusesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5955-6
dc.identifier.doihttp://dx.doi.org/10.25646/5920
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirusesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/1999-4915/10/10/546none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume10none
local.edoc.container-issue10none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage12none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

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