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2019-01-31Zeitschriftenartikel DOI: 10.25646/5922
Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks
dc.contributor.authorBartolini, Barbara
dc.contributor.authorGruber, Cesare E. M.
dc.contributor.authorKoopmans, Marion
dc.contributor.authorAvšič, Tatjana
dc.contributor.authorBino, Sylvia
dc.contributor.authorChristova, Iva
dc.contributor.authorGrunow, Roland
dc.contributor.authorHewson, Roger
dc.contributor.authorKorukluoglu, Gulay
dc.contributor.authorMenel Lemos, Cinthia
dc.contributor.authorMirazimi, Ali
dc.contributor.authorPapa, Anna
dc.contributor.authorPaz Sanchez-Seco, Maria
dc.contributor.authorSauer, Aisha V.
dc.contributor.authorZeller, Hervè
dc.contributor.authorNisii, Carla
dc.contributor.authorCapobianchi, Maria R.
dc.contributor.authorIppolito, Giuseppe
dc.contributor.authorReusken, Chantal B.
dc.contributor.authorDi Caro, Antonino
dc.date.accessioned2019-03-05T07:43:33Z
dc.date.available2019-03-05T07:43:33Z
dc.date.issued2019-01-31none
dc.identifier.other10.2807/1560-7917.ES.2019.24.5.1800093
dc.identifier.urihttp://edoc.rki.de/176904/5957
dc.description.abstractBackground Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks. Aims To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. Methods We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVD-LabNet (Emerging Viral Diseases-Expert Laboratory Network). Results Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin. Conclusion No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectCCHFeng
dc.subjectCCHFVeng
dc.subjectCrimean-Congo haemorrhagic fever viruseng
dc.subjectEuropean networkeng
dc.subjectemerging diseaseseng
dc.subjectlaboratory preparednesseng
dc.subjectlaboratory responseeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleLaboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networksnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5957-7
dc.identifier.doihttp://dx.doi.org/10.25646/5922
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.5.1800093#abstract_contentnone
local.edoc.container-publisher-nameECDCnone
local.edoc.container-volume24none
local.edoc.container-issue5none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage14none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

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