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2019-01-24Zeitschriftenartikel DOI: 10.25646/5926
NTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases
dc.contributor.authorBinh, Mai Thanh
dc.contributor.authorXuan Hoan, Nghiem
dc.contributor.authorVan Tong, Hoang
dc.contributor.authorSy, Bui Tien
dc.contributor.authorTrung, Ngo Tat
dc.contributor.authorBock, C. Thomas
dc.contributor.authorToan, Nguyen Linh
dc.contributor.authorSong, Le Huu
dc.contributor.authorBang, Mai Hong
dc.contributor.authorMeyer, Christian G.
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2019-03-05T09:31:13Z
dc.date.available2019-03-05T09:31:13Z
dc.date.issued2019-01-24none
dc.identifier.other10.1016/j.ijid.2019.01.038
dc.identifier.urihttp://edoc.rki.de/176904/5961
dc.description.abstractObjectives To determine potential associations of the rs2296651 variant (c.800C > T, S267F) of NTCP with HBV and HBV plus concomitant HDV infection as well as with the progression of related liver diseases. Methods The S267F variant was genotyped by DNA sequencing in 620 HBV-infected patients and 214 healthy controls (HCs). Among the patients, 450 individuals were tested for HDV by a nested PCR assay. Logistic regression was applied to examine the association. Results The S267F variant was found more frequently among HCs (16%) compared to HBV-infected (6%) and HBV-HDV co-infected patients (3%) (HBV patients vs HC: OR = 0.32, P = 0.00002 and HDV patients vs. HC: OR = 0.17, P = 0.018). The frequency of S267F variant was inversely correlated with CHB, LC or HCC patients compared with HCs (OR = 0.31, P = 0.001; OR = 0.32, P = 0.013; OR = 0.34, P = 0.002, respectively). S267F variant was also associated with decreased risk of the development of advanced liver cirrhosis (LC) and hepatocellular carcinoma (HCC) (Child B and C vs. Child A, OR = 0.26, adjusted P = 0.016; BCLC B,C,D vs. BCLC A, OR = 0.038, P = 0.045, respectively). In addition, patients with the genotype CT had lower levels of AST, ALT, total and direct bilirubin as well as higher platelet counts, indicating an association with a more favorable clinical outcome. Conclusion The NTCP S267F variant of the SLC10A1 gene exhibits protective effects against HBV and HDV infection and is associated with a reduced risk of developing to advanced stages of LC and HCC.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectHBVeng
dc.subjectHDVeng
dc.subjectNTCPeng
dc.subjectS267Feng
dc.subjectLiver diseaseseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleNTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseasesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5961-8
dc.identifier.doihttp://dx.doi.org/10.25646/5926
dc.type.versionpublishedVersionnone
local.edoc.container-titleInternational Journal of Infectious Diseasesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/science/article/pii/S1201971219300499?via%3Dihubnone
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume2019none
local.edoc.container-issue80none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage147none
local.edoc.container-lastpage152none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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