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2018-12-18Zeitschriftenartikel DOI: 10.25646/5966
Association between random glucose and all-cause mortality: findings from the mortality follow-up of the German National Health Interview and Examination Survey 1998
dc.contributor.authorBaumert, Jens
dc.contributor.authorHeidemann, Christin
dc.contributor.authorPaprott, Rebecca
dc.contributor.authorDu, Yong
dc.contributor.authorScheidt-Nave, Christa
dc.date.accessioned2019-03-21T07:40:48Z
dc.date.available2019-03-21T07:40:48Z
dc.date.issued2018-12-18none
dc.identifier.other10.1186/s12902-018-0319-2
dc.identifier.urihttp://edoc.rki.de/176904/6001
dc.description.abstractBackground Random glucose is widely measured in epidemiological studies and in the clinical setting when standardized fasting protocols and oral glucose tolerance testing or HbA1c measuring are not feasible. The relationship between random glucose and all-cause mortality has hardly been studied so far and was examined in the present study. Methods We ascertained mortality status among 5955 persons aged 18–79 years and free of known diabetes when participating in the German National Health Interview and Examination Survey 1998 (mean observation time 11.7 years, 458 deaths). Cox regression was applied to analyze the association of random serum glucose with all-cause mortality taken potential confounders into account. Relative mortality risks were estimated as hazard ratios (HRs) with 95% confidence intervals (CIs) modeling random glucose as categorical or continuous variable. Results Compared to random glucose levels of 4.3 - < 5.3 mmol/L, HRs (95% CIs) were 1.94 (0.85–4.45) for levels < 4.3 mmol/L and 1.16 (0.89–1.50), 1.20 (0.91–1.58), 1.42 (0.88–2.29), 2.02 (1.26–3.25) and 4.71 (2.20–10.10) for levels 5.3 - < 5.8, 5.8 - < 6.8, 6.8 - < 7.8, 7.8 - < 11.1 and ≥ 11.1 mmol/L, adjusted for age, sex, lifestyle, anthropometry and chronic diseases. An additional adjustment for fasting time or HbA1c yielded similar estimates. Modeling continuous random glucose by restricted cubic spline functions revealed comparable findings. Conclusions In the present epidemiological study drawn from the general population, random glucose showed a significant association with all-cause mortality, independent of main potential confounders. Thus, random glucose measures are highly relevant to health risk assessment among people without known diabetes when fasting glucose or HbA1c are difficult to obtain.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectRandom glucoseeng
dc.subjectAll-cause mortalityeng
dc.subjectFasting timeeng
dc.subjectDiabetes preventioneng
dc.subjectPopulation-based studyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleAssociation between random glucose and all-cause mortality: findings from the mortality follow-up of the German National Health Interview and Examination Survey 1998none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6001-6
dc.identifier.doihttp://dx.doi.org/10.25646/5966
dc.type.versionpublishedVersionnone
local.edoc.container-titleBMC Endocrine Disordersnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-018-0319-2none
local.edoc.container-publisher-nameBioMed Centralnone
local.edoc.container-volume18none
local.edoc.container-issue95none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage10none
local.edoc.rki-departmentEpidemiologie und Gesundheitsmonitoringnone
dc.description.versionPeer Reviewednone

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