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2018-11-08Zeitschriftenartikel DOI: 10.25646/6014
Reduction of the survival time of pig xenotransplants by porcine cytomegalovirus
dc.contributor.authorDenner, Joachim
dc.date.accessioned2019-03-27T13:29:44Z
dc.date.available2019-03-27T13:29:44Z
dc.date.issued2018-11-08none
dc.identifier.other10.1186/s12985-018-1088-2
dc.identifier.urihttp://edoc.rki.de/176904/6049
dc.description.abstractBackground Xenotransplantation using pig cells, tissues and organs may help to overcome the shortage of human tissues and organs for the treatment of tissue and organ failure. Progress in the prevention of immunological rejection using genetically modified pigs and new, more effective, immunosuppression regimens will allow clinical application of xenotransplantation in near future. However, xenotransplantation may be associated with the transmission of potentially zoonotic porcine microorganisms. Until now the only xenotransplantation-associated transmission was the transmission of the porcine cytomegalovirus (PCMV) into non-human primates. PCMV caused a significant reduction of the survival time of the pig transplant. Main body of the abstract Here the available publications were analysed in order to establish the mechanism how PCMV shortened the survival time of xenotransplants. PCMV is a herpesvirus related to the human cytomegalovirus and the human herpesviruses 6 and 7. These three human herpesviruses can cause serious disease among immunocompromised human individuals, including transplant recipients. It was shown that PCMV predominantly contributes to the reduction of transplant survival in non-human primates by disruption of the coagulation system and by suppression and exhaustion of the immune system. Conclusion Although it is still unknown whether PCMV infects primate cells including human cells, indirect mechanism of the virus infection may cause reduction of the xenotransplant survival in future clinical trials and therefore PCMV has to be eliminated from donor pigs.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectPorcine cytomegaloviruseng
dc.subjectXenotransplantationeng
dc.subjectHerpesviruseseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleReduction of the survival time of pig xenotransplants by porcine cytomegalovirusnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6049-7
dc.identifier.doihttp://dx.doi.org/10.25646/6014
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirology Journalnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://virologyj.biomedcentral.com/articles/10.1186/s12985-018-1088-2none
local.edoc.container-publisher-nameBioMed Centralnone
local.edoc.container-volume15none
local.edoc.container-issue171none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage7none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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