Zur Kurzanzeige

2018-05-10Zeitschriftenartikel DOI: 10.25646/6019
Case-control study on risk factors for acute hepatitis E in Germany, 2012 to 2014
dc.contributor.authorFaber, Mirko
dc.contributor.authorAskar, Mona
dc.contributor.authorStark, Klaus
dc.date.accessioned2019-03-28T09:01:40Z
dc.date.available2019-03-28T09:01:40Z
dc.date.issued2018-05-10none
dc.identifier.other10.2807/1560-7917.ES.2018.23.19.17-00469
dc.identifier.urihttp://edoc.rki.de/176904/6054
dc.description.abstractBackground Notified cases of hepatitis E have increased 40-fold in the past 10 years in Germany. Food safety is a major concern as hepatitis E virus (HEV) RNA has been detected in ready-to-eat retail-level food products. The objective of this case–control study was to assess risk factors for autochthonous symptomatic hepatitis E and explore reasons for delays in diagnosis. Methods: Demographic, clinical and exposure data from notified hepatitis E cases and individually matched population controls were collected in semi-standardised telephone interviews. Conditional logistic regression analysis was used to calculate matched odds ratios (mOR) and population attributable fractions (PAF). Results: In total, 270 cases and 1,159 controls were included (mean age 53 years, 61% men in both groups). Associated with disease were: consumption of undercooked pork liver, pork, wild boar meat, frankfurters, liver sausage and raw vegetables; contact with waste water (occupational) and various host factors (mORs between 1.9 and 34.1, p value < 0.03). PAF for frankfurters and liver sausage were 17.6%, and 23.6%, respectively. There were statistically significant differences in the clinical presentation and hospitalisation proportion of acute hepatitis E in men and women. Diagnosis was preceded by more invasive procedures in 29.2% of patients, suggesting that hepatitis E was not immediately considered as a common differential diagnosis. Conclusions: Our study suggests that there are indeed sex-specific differences in disease development and lends important epidemiological evidence to specific ready-to-eat pork products as a major source for autochthonous hepatitis E. A review of existing consumer recommendations and production methods may be indicated.ger
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectHepatitis Eeng
dc.subjectcase-control studyeng
dc.subjecthumaneng
dc.subjectrisk factorseng
dc.subjectGermanyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleCase-control study on risk factors for acute hepatitis E in Germany, 2012 to 2014none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6054-1
dc.identifier.doihttp://dx.doi.org/10.25646/6019
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2018.23.19.17-00469#abstract_contentnone
local.edoc.container-publisher-nameInstitut de Veille Sanitairenone
local.edoc.container-volume23none
local.edoc.container-issue19none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage8none
local.edoc.rki-departmentInfektionsepidemiologienone
dc.description.versionPeer Reviewednone

Zur Kurzanzeige