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2018-07-12Zeitschriftenartikel DOI: 10.25646/6033
Yellow fever in the diagnostics laboratory
dc.contributor.authorDomingo, Christina
dc.contributor.authorCharrel, Rémi N.
dc.contributor.authorSchmidt-Chanasit, Jonas
dc.contributor.authorZeller, Hervé
dc.contributor.authorReusken, Chantal
dc.date.accessioned2019-03-29T09:02:47Z
dc.date.available2019-03-29T09:02:47Z
dc.date.issued2018-07-12none
dc.identifier.other10.1038/s41426-018-0128-8
dc.identifier.urihttp://edoc.rki.de/176904/6068
dc.description.abstractYellow fever (YF) remains a public health issue in endemic areas despite the availability of a safe and effective vaccine. In 2015–2016, urban outbreaks of YF were declared in Angola and the Democratic Republic of Congo, and a sylvatic outbreak has been ongoing in Brazil since December 2016. Of great concern is the risk of urban transmission cycles taking hold in Brazil and the possible spread to countries with susceptible populations and competent vectors. Vaccination remains the cornerstone of an outbreak response, but a low vaccine stockpile has forced a sparing-dose strategy, which has thus far been implemented in affected African countries and now in Brazil. Accurate laboratory confirmation of cases is critical for efficient outbreak control. A dearth of validated commercial assays for YF, however, and the shortcomings of serological methods make it challenging to implement YF diagnostics outside of reference laboratories. We examine the advantages and drawbacks of existing assays to identify the barriers to timely and efficient laboratory diagnosis. We stress the need to develop new diagnostic tools to meet current challenges in the fight against YF.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleYellow fever in the diagnostics laboratorynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6068-9
dc.identifier.doihttp://dx.doi.org/10.25646/6033
dc.type.versionpublishedVersionnone
local.edoc.container-titleEmerging Microbes & Infectionsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41426-018-0128-8none
local.edoc.container-publisher-nameNature Publishing Groupnone
local.edoc.container-volume7none
local.edoc.container-issue129none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage15none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

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