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2018-07-19Zeitschriftenartikel DOI: 10.25646/6034
A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential
dc.contributor.authorGrund, Christian
dc.contributor.authorHoffmann, Donata
dc.contributor.authorUlrich, Reiner
dc.contributor.authorNaguib, Mahmoud
dc.contributor.authorSchinköthe, Jan
dc.contributor.authorHoffmann, Bernd
dc.contributor.authorHarder, Timm
dc.contributor.authorSaenger, Sandra
dc.contributor.authorZscheppang, Katja
dc.contributor.authorTönnies, Mario
dc.contributor.authorHippenstiel, Stefan
dc.contributor.authorHocke, Andreas
dc.contributor.authorWolff, Thorsten
dc.contributor.authorBeer, Martin
dc.date.accessioned2019-03-29T09:14:51Z
dc.date.available2019-03-29T09:14:51Z
dc.date.issued2018-07-19none
dc.identifier.other10.1038/s41426-018-0130-1
dc.identifier.urihttp://edoc.rki.de/176904/6069
dc.description.abstractWe investigated in a unique setup of animal models and a human lung explant culture biological properties, including zoonotic potential, of a representative 2016 highly pathogenic avian influenza virus (HPAIV) H5N8, clade 2.3.4.4 group B (H5N8B), that spread rapidly in a huge and ongoing outbreak series in Europe and caused high mortality in waterfowl and domestic birds. HPAIV H5N8B showed increased virulence with rapid onset of severe disease and mortality in Pekin ducks due to pronounced neuro- and hepatotropism. Cross-species infection was evaluated in mice, ferrets, and in a human lung explant culture model. While the H5N8B isolate was highly virulent for Balb/c mice, virulence and transmissibility were grossly reduced in ferrets, which was mirrored by marginal replication in human lung cultures infected ex vivo. Our data indicate that the 2016 HPAIV H5N8B is avian-adapted with augmented virulence for waterfowl, but has low zoonotic potential. The here tested combination of animal studies with the inoculation of human explants provides a promising future workflow to evaluate zoonotic potential, mammalian replication competence and avian virulence of HPAIV.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleA novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potentialnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6069-8
dc.identifier.doihttp://dx.doi.org/10.25646/6034
dc.type.versionpublishedVersionnone
local.edoc.container-titleEmerging Microbes & Infectionsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41426-018-0130-1#rightslinknone
local.edoc.container-publisher-nameNature Publishing Groupnone
local.edoc.container-volume7none
local.edoc.container-issue132none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage14none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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