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2019-03-08Zeitschriftenartikel DOI: 10.25646/6035
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
dc.contributor.authorHendriksen, Rene S.
dc.contributor.authorMunk, Patrick
dc.contributor.authorNjage, Patrick
dc.contributor.authorvan Bunnik, Bram
dc.contributor.authorMcNally, Luke
dc.contributor.authorLukjancenko, Oksana
dc.contributor.authorRöder, Timo
dc.contributor.authorNieuwenhuijse, David
dc.contributor.authorKarlsmose Pedersen, Susanne
dc.contributor.authorKjeldgaard, Jette
dc.contributor.authorKaas, Rolf S.
dc.contributor.authorLanken Conradsen Clausen, Philip Thomas
dc.contributor.authorVogt, Josef Korbinian
dc.contributor.authorLeekitcharoenphon, Pimlapas
dc.contributor.authorvan de Schans, Milou G. M.
dc.contributor.authorZuidema, Tina
dc.contributor.authorde Roda Husman, Ana Maria
dc.contributor.authorRasmussen, Simon
dc.contributor.authorPetersen, Bent
dc.contributor.authorThe Global Sewage Surveillance project consortium
dc.contributor.authorAmid, Clara
dc.contributor.authorCochrane, Guy
dc.contributor.authorSicheritz-Ponten, Thomas
dc.contributor.authorSchmitt, Heike
dc.contributor.authorAlvarez, Jorge Raul Matheu
dc.contributor.authorAidara-Kane, Awa
dc.contributor.authorPamp, Sünje J.
dc.contributor.authorLund, Ole
dc.contributor.authorHald, Tine
dc.contributor.authorWoolhouse, Mark
dc.contributor.authorKoopmans, Marion P.
dc.contributor.authorVigre, Håkan
dc.contributor.authorNordahl Petersen, Thomas
dc.contributor.authorAarestrup, Frank M.
dc.date.accessioned2019-03-29T09:39:46Z
dc.date.available2019-03-29T09:39:46Z
dc.date.issued2019-03-08none
dc.identifier.other10.1038/s41467-019-08853-3
dc.identifier.urihttp://edoc.rki.de/176904/6070
dc.description.abstractAntimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleGlobal monitoring of antimicrobial resistance based on metagenomics analyses of urban sewagenone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6070-9
dc.identifier.doihttp://dx.doi.org/10.25646/6035
dc.type.versionpublishedVersionnone
local.edoc.container-titleNature Communicationsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41467-019-08853-3#article-infonone
local.edoc.container-publisher-nameNature Publishing Groupnone
local.edoc.container-volume10none
local.edoc.container-issue1124none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage12none
local.edoc.rki-departmentZentrum für Biologische Gefahren und Spezielle Pathogenenone
dc.description.versionPeer Reviewednone

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