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2017-11-10Zeitschriftenartikel DOI: 10.25646/6054
2015/16 I‐MOVE/I‐MOVE+ multicentre case‐control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage‐mismatched influenza B among children
dc.contributor.authorKissling, Esther
dc.contributor.authorValenciano, Marta
dc.contributor.authorPozo, Francisco
dc.contributor.authorVilcu, Ana-Maria
dc.contributor.authorReuss, Annicka
dc.contributor.authorRizzo, Caterina
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorHorváth, Judit Krisztina
dc.contributor.authorBrytting, Mia
dc.contributor.authorDomegan, Lisa
dc.contributor.authorKorczyńska, Monika
dc.contributor.authorMeijer, Adam
dc.contributor.authorMachado, Ausenda
dc.contributor.authorIvanciuc, Alina
dc.contributor.authorVišekruna Vučina, Vesna
dc.contributor.authorvan der Werf, Sylvie
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorBella, Antonino
dc.contributor.authorGherasim, Alin
dc.contributor.authorFerenczi, Annamária
dc.contributor.authorZakikhany, Katherina
dc.contributor.authorO'Donnell, Joan
dc.contributor.authorParadowska-Stankiewicz, Iwona
dc.contributor.authorDijkstra, Frederika
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorLazar, Mihaela
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorJohansen, Kari
dc.contributor.authorMoren, Alain
dc.contributor.authorI-MOVE/I-MOVE+ study team
dc.date.accessioned2019-04-09T10:01:11Z
dc.date.available2019-04-09T10:01:11Z
dc.date.issued2017-11-10none
dc.identifier.other10.1111/irv.12520
dc.identifier.urihttp://edoc.rki.de/176904/6089
dc.description.abstractBackground During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine. Methods We used the test‐negative design in a multicentre case‐control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically attended influenza‐like illness (ILI) laboratory‐confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients and a random sample of influenza‐positive swabs was sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group. Results We included 11 430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5‐46.7). Among those aged 0‐14, 15‐64 and ≥65 years, VE against A(H1N1)pdm09 was 31.9% (95% CI: −32.3 to 65.0), 41.4% (95% CI: 20.5‐56.7) and 13.2% (95% CI: −38.0 to 45.3), respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95% CI: −4.1 to 56.7). Among those aged 0‐14, 15‐64 and ≥65 years, VE against influenza B was −47.6% (95% CI: −124.9 to 3.1), 27.3% (95% CI: −4.6 to 49.4) and 9.3% (95% CI: −44.1 to 42.9), respectively. Conclusions Vaccine effectiveness (VE) against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65 years. Vaccine effectiveness (VE) against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection is needed to understand the VE results against influenza B in the context of a mismatched vaccine.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectcase-control studyeng
dc.subjectinfluenzaeng
dc.subjectinfluenza vaccineeng
dc.subjectmulticentre studyeng
dc.subjectvaccine effeeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.title2015/16 I‐MOVE/I‐MOVE+ multicentre case‐control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage‐mismatched influenza B among childrennone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6089-9
dc.identifier.doihttp://dx.doi.org/10.25646/6054
dc.type.versionpublishedVersionnone
local.edoc.container-titleInfluenza and Other Respiratory Virusesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/irv.12520none
local.edoc.container-publisher-nameWiley-Blackwellnone
local.edoc.container-volume12none
local.edoc.container-issue4none
local.edoc.container-reportyear2017none
local.edoc.container-year2017none
local.edoc.container-firstpage423none
local.edoc.container-lastpage437none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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