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2018-05-18Zeitschriftenartikel DOI: 10.25646/6055
Comment on “The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans”
dc.contributor.authorKrücken, Jürgen
dc.contributor.authorFraundorfer, Kira
dc.contributor.authorMugisha, Jean Claude
dc.contributor.authorRamünke, Sabrina
dc.contributor.authorSifft, Kevin C.
dc.contributor.authorGeus, Dominik
dc.contributor.authorHabarugira, Felix
dc.contributor.authorNdoli, Jules
dc.contributor.authorSendegeya, Augustin
dc.contributor.authorMukampunga, Caritas
dc.contributor.authorAebischer, Toni
dc.contributor.authorMcKay-Demeler, Janina
dc.contributor.authorGahutu, Jean Bosco
dc.contributor.authorMockenhaupt, Frank P.
dc.contributor.authorvon Samson-Himmelstjerna, Georg
dc.date.accessioned2019-04-09T11:36:28Z
dc.date.available2019-04-09T11:36:28Z
dc.date.issued2018-05-18none
dc.identifier.other10.1016/j.ijpddr.2018.05.004
dc.identifier.urihttp://edoc.rki.de/176904/6090
dc.description.abstractA recent publication by Levecke et al. (Int. J. Parasitol, 2018, 8, 67–69) provides important insights into the kinetics of worm expulsion from humans following treatment with albendazole. This is an important aspect of determining the optimal time-point for post treatment sampling to examine anthelmintic drug efficacy. The authors conclude that for the determination of drug efficacy against Ascaris, samples should be taken not before day 14 and recommend a period between days 14 and 21. Using this recommendation, they conclude that previous data (Krücken et al., 2017; Int. J. Parasitol, 7, 262–271) showing a reduction of egg shedding by 75.4% in schoolchildren in Rwanda and our conclusions from these data should be interpreted with caution. In reply to this, we would like to indicate that the very low efficacy of 0% in one school and 52–56% in three other schools, while the drug was fully efficient in other schools, cannot simply be explained by the time point of sampling. Moreover, there was no correlation between the sampling day and albendazole efficacy. We would also like to indicate that we very carefully interpreted our data and, for example, nowhere claimed that we found anthelmintic resistance. Rather, we stated that our data indicated that benzimidazole resistance may be suspected in the study population. We strongly agree that the data presented by Levecke et al. suggests that recommendations for efficacy testing of anthelmintic drugs should be revised.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleComment on “The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans”none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6090-4
dc.identifier.doihttp://dx.doi.org/10.25646/6055
dc.type.versionpublishedVersionnone
local.edoc.container-titleInternational Journal for Parasitology: Drugs and Drug Resistancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/science/article/pii/S2211320718300514?via%3Dihubnone
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume8none
local.edoc.container-issue2none
local.edoc.container-reportyear2018none
local.edoc.container-year2018none
local.edoc.container-firstpage329none
local.edoc.container-lastpage330none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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