Show simple item record

2019-07-22Zeitschriftenartikel DOI: 10.25646/6279
Susceptibility of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) to chlorhexidine digluconate, octenidine dihydrochloride, polyhexanide, PVP-iodine and triclosan in comparison to hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA): a standardized comparison
dc.contributor.authorDittmann, Kathleen
dc.contributor.authorSchmidt, Thomas
dc.contributor.authorMüller, Gerald
dc.contributor.authorCuny, Christiane
dc.contributor.authorHoltfreter, Silva
dc.contributor.authorTroitzsch, Daniel
dc.contributor.authorPfaff, Peter
dc.contributor.authorHübner, Nils-Olaf
dc.date.accessioned2019-09-18T11:44:59Z
dc.date.available2019-09-18T11:44:59Z
dc.date.issued2019-07-22none
dc.identifier.other10.1186/s13756-019-0580-9
dc.identifier.urihttp://edoc.rki.de/176904/6294
dc.description.abstractBackground Recent publications have raised concerns of reduced susceptibilities of clinical bacterial isolates towards biocides. This study presents a comparative investigation of the susceptibility of livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA), hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA) to the commonly used antiseptics chlorhexidine (CHX), octenidine (OCT), polyhexanide (PHMB), PVP-iodine (PVP-I) and triclosan (TCX) based on internationally accepted standards. Methods In total, 28 (18 LA-, 5 HA- and 5 CA) genetically characterized MRSA strains representing a broad spectrum of hosts, clonal complexes and spa-types, as well as the reference methicillin-sensitive Staphylococcus aureus (MSSA) strain ATCC 6538, were selected. Minimal inhibitory concentration (MIC) and minimal microbicidal concentration (MBC) were determined in accordance with DIN 58940–7, 58940–8 and DIN EN ISO 20776-1. The microbicidal efficacy was determined in accordance with DIN EN 1040. Results Results from the MIC/MBC and quantitative suspension tests revealed differences between antiseptic substances but not between epidemiological groups of MRSA strains. OCT and PHMB were the most active substances with a minimal MIC of 1 mg/L, followed by CHX (2 mg/L), TCX (32 mg/L) and finally PVP-I (1024 mg/L). The MSSA reference strain showed a tendency to a higher susceptibility compared to the MRSA strains. Conclusions This investigation of the susceptibility of a range of LA-, HA- and CA-MRSA strains using standardized conditions gave no indication that LA-MRSA strains are less susceptible to commonly used antiseptics compared to HA- and CA-MRSA strains.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectMRSAeng
dc.subjectResistanceeng
dc.subjectDecolonizationeng
dc.subjectAntisepsiseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSusceptibility of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) to chlorhexidine digluconate, octenidine dihydrochloride, polyhexanide, PVP-iodine and triclosan in comparison to hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA): a standardized comparisonnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6294-8
dc.identifier.doihttp://dx.doi.org/10.25646/6279
dc.type.versionpublishedVersionnone
local.edoc.container-titleAntimicrobial Resistance & Infection Controlnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://aricjournal.biomedcentral.com/articles/10.1186/s13756-019-0580-9#Abs1none
local.edoc.container-publisher-nameBioMed Centralnone
local.edoc.container-volume8none
local.edoc.container-issue122none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage9none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

Show simple item record