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2019-07-11Zeitschriftenartikel DOI: 10.25646/6319
Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus
dc.contributor.authorEnkirch, Theresa
dc.contributor.authorSeveri, Ettore
dc.contributor.authorVennema, Harry
dc.contributor.authorThornton, Lelia
dc.contributor.authorDean, Jonathan
dc.contributor.authorBorg, Maria-Louise
dc.contributor.authorCiccaglione, Anna Rita
dc.contributor.authorBruni, Roberto
dc.contributor.authorChristova, Iva
dc.contributor.authorNgui, Siew Lin
dc.contributor.authorBalogun, Koye
dc.contributor.authorNěmeček, Vratislav
dc.contributor.authorKontio, Mia
dc.contributor.authorTakács, Mária
dc.contributor.authorHettmann, Andrea
dc.contributor.authorKorotinska, Rita
dc.contributor.authorLöve, Arthur
dc.contributor.authorAvellón, Ana
dc.contributor.authorMuñoz-Chimeno, Milagros
dc.contributor.authorde Sousa, Rita
dc.contributor.authorJanta, Denisa
dc.contributor.authorEpštein, Jevgenia
dc.contributor.authorKlamer, Sofieke
dc.contributor.authorSuin, Vanessa
dc.contributor.authorAberle, Stephan W.
dc.contributor.authorHolzmann, Heidemarie
dc.contributor.authorMellou, Kassiani
dc.contributor.authorLundberg Ederth, Josefine
dc.contributor.authorSundqvist, Lena
dc.contributor.authorRoque-Afonso, Anne-Marie
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorPoljak, Mario
dc.contributor.authorVold, Line
dc.contributor.authorStene-Johansen, Kathrine
dc.contributor.authorMidgley, Sofie
dc.contributor.authorKølsen Fischer, Thea
dc.contributor.authorFaber, Mirko
dc.contributor.authorWenzel, Jürgen J.
dc.contributor.authorTakkinen, Johanna
dc.contributor.authorLeitmeyer, Katrin
dc.date.accessioned2019-10-15T12:03:30Z
dc.date.available2019-10-15T12:03:30Z
dc.date.issued2019-07-11none
dc.identifier.other10.2807/1560-7917.ES.2019.24.28.1800397
dc.identifier.urihttp://edoc.rki.de/176904/6332
dc.description.abstractIntroduction Sequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive. Aim The objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses. Methods In 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases’ samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods. Results Of 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths. Conclusions While HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectEuropean Unioneng
dc.subjectHAVeng
dc.subjectcapacity buildingeng
dc.subjectfoodborne diseaseseng
dc.subjecthepatitis A viruseng
dc.subjectsequence analysiseng
dc.subjectsurveys and questionnaireseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleImproving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virusnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6332-5
dc.identifier.doihttp://dx.doi.org/10.25646/6319
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.28.1800397#html_fulltextnone
local.edoc.container-publisher-nameInstitut de Veille Sanitairenone
local.edoc.container-volume24none
local.edoc.container-issue28none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage11none
local.edoc.rki-departmentInfektionsepidemiologienone
dc.description.versionPeer Reviewednone

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