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2019-08-08Zeitschriftenartikel DOI: 10.25646/6321
Molecular and epidemiological characteristics of human Puumala and Dobrava-Belgrade hantavirus infections, Germany, 2001 to 2017
dc.contributor.authorFaber, Mirko
dc.contributor.authorKrüger, Detlev H.
dc.contributor.authorAuste, Brita
dc.contributor.authorStark, Klaus
dc.contributor.authorHofmann, Jörg
dc.contributor.authorWeiss, Sabrina
dc.date.accessioned2019-10-16T07:03:42Z
dc.date.available2019-10-16T07:03:42Z
dc.date.issued2019-08-08none
dc.identifier.other10.2807/1560-7917.ES.2019.24.32.1800675
dc.identifier.urihttp://edoc.rki.de/176904/6334
dc.description.abstractIntroduction Two hantavirus species, Puumala (PUUV) and Dobrava-Belgrade (DOBV) virus (genotype Kurkino), are endemic in Germany. Recent PUUV outbreaks raised questions concerning increasing frequency of outbreaks and expansion of PUUV endemic areas. Aims To describe the epidemiology of human PUUV and DOBV infections in Germany. Methods We conducted an observational retrospective study analysing national hantavirus surveillance data notified to the national public health institute and hantavirus nucleotide sequences from patients collected at the national consultation laboratory between 2001 and 2017. Matching molecular sequences with surveillance data, we conducted epidemiological, phylogenetic and phylogeographic analyses. Results In total, 12,148 cases of symptomatic hantavirus infection were notified 2001–17 (mean annual incidence: 0.87/100,000; range: 0.09–3.51). PUUV infections showed a highly variable space-time disease incidence pattern, causing large outbreaks every 2–3 years with peaks in early summer and up to 3,000 annually reported cases. Sex-specific differences in disease presentation were observed. Of 202 PUUV nucleotide sequences obtained from cases, 189 (93.6%) fall into well-supported phylogenetic clusters corresponding to different endemic areas in Germany. DOBV infections caused few, mostly sporadic cases in autumn and winter in the north and east of Germany. Conclusions The frequency of PUUV outbreaks increased between 2001 and 2017 but our data does not support the suggested expansion of endemic areas. The epidemiology of PUUV and DOBV-Kurkino infections differs in several aspects. Moreover, the latter are relatively rare and combining efforts and data of several countries to identify risk factors and develop specific recommendations for prevention could be worthwhile.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectCentral Europeeng
dc.subjectDisease Notificationeng
dc.subjectDobrava-belgrade viruseng
dc.subjectEnvironmental Exposureeng
dc.subjectGermanyeng
dc.subjectHFRSeng
dc.subjectHantaviruseng
dc.subjectHumanseng
dc.subjectMolecular epidemiologyeng
dc.subjectOutbreakeng
dc.subjectPhylogeographyeng
dc.subjectPuumala viruseng
dc.subjectZoonoseseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleMolecular and epidemiological characteristics of human Puumala and Dobrava-Belgrade hantavirus infections, Germany, 2001 to 2017none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6334-6
dc.identifier.doihttp://dx.doi.org/10.25646/6321
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.32.1800675#html_fulltextnone
local.edoc.container-publisher-nameInstitut de Veille Sanitairenone
local.edoc.container-volume24none
local.edoc.container-issue32none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage11none
local.edoc.rki-departmentInfektionsepidemiologienone
dc.description.versionPeer Reviewednone

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