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2019-06-26Zeitschriftenartikel DOI: 10.25646/6551
High Hepatitis E virus (HEV) Positivity Among Domestic Pigs and Risk of HEV Infection of Individuals Occupationally Exposed to Pigs and Pork Meat in Hanoi, Vietnam
dc.contributor.authorXuan Hoan, Nghiem
dc.contributor.authorXuan Huy, Pham
dc.contributor.authorTien Sy, Bui
dc.contributor.authorMeyer, Christian G.
dc.contributor.authorVan Son, Trinh
dc.contributor.authorThanh Binh, Mai
dc.contributor.authorPhuong Giang, Dao
dc.contributor.authorTu Anh, Dam
dc.contributor.authorBock, Claus-Thomas
dc.contributor.authorWang, Bo
dc.contributor.authorVan Tong, Hoang
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorHu Song, Lee
dc.contributor.authorLinh Toan, Nguyen
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2020-03-17T10:55:48Z
dc.date.available2020-03-17T10:55:48Z
dc.date.issued2019-06-26none
dc.identifier.other10.1093/ofid/ofz306
dc.identifier.urihttp://edoc.rki.de/176904/6520
dc.description.abstractBackground Hepatitis E virus (HEV) infection can occur through consumption of undercooked pork meat or exposure to animal feces. Because there are scarce data only in developing countries, we assessed whether pigs might be a potential source of human HEV infections in Vietnam. In addition, we determined anti-HEV seroprevalences in the general population and in individuals professionally exposed to pigs and pork meat. Methods The study took place in Hanoi, Vietnam. Liver tissues from domestic pigs (n = 210) and serum samples obtained from individuals occupationally exposed to pigs and pork meat (n = 283) and from unexposed healthy controls (n = 168) were screened for HEV-ribonucleic acid (RNA) by reverse-transcription polymerase chain reaction. The exposed group was divided into pork meat vendors (n = 81), pig farmers (n = 96), and slaughterers (n = 106). Serum samples were subjected to HEV immunoglobulin (Ig)G and IgM enzyme-linked immunosorbent assays. The HEV genotypes were assessed by direct sequencing, followed by phylogenetic analyses. Results Hepatitis E virus seroprevalence was higher among persons occupationally exposed to pigs/pork meat compared with unexposed individuals (anti-HEV IgM 11% vs 6%, P = .07; anti-HEV IgG 53% vs 31%, P < .0001). Positivity of anti-HEV IgG among slaughterhouse staff was 66%, followed by 51% in pig-farmers and 38% in pork meat vendors (P = .00073). A similar trend was observed for IgM positivity. Of the pig liver tissues, 26 of 210 (12.4%) were positive for HEV-RNA and assessed to be HEV genotype 3. Conclusions Hepatitis E virus circulates in domestic pigs in Hanoi and constitutes a permanent zoonotic disease risk. The high HEV seroprevalence among occupationally exposed individuals indicates an associated risk of HEV infection.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjecthepatitis E viruseng
dc.subjectoccupationally exposedeng
dc.subjectpigseng
dc.subjectpork meateng
dc.subjectzoonoseseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHigh Hepatitis E virus (HEV) Positivity Among Domestic Pigs and Risk of HEV Infection of Individuals Occupationally Exposed to Pigs and Pork Meat in Hanoi, Vietnamnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6520-9
dc.identifier.doihttp://dx.doi.org/10.25646/6551
dc.type.versionpublishedVersionnone
local.edoc.container-titleOpen Forum Infectious Diseasesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://academic.oup.com/ofid/article/6/9/ofz306/5523738none
local.edoc.container-publisher-nameOxford University Pressnone
local.edoc.container-volume6none
local.edoc.container-issue9none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage7none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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