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2020-02-16Zeitschriftenartikel DOI: 10.25646/6580
Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana
dc.contributor.authorDi Christanziano, Veronica
dc.contributor.authorWeimer, Kristina
dc.contributor.authorBöttcher, Sindy
dc.contributor.authorSarfo, Fred Stephen
dc.contributor.authorDompreh, Albert
dc.contributor.authorCesar, Lucio-Garcia
dc.contributor.authorKnops, Elena
dc.contributor.authorHeger, Eva
dc.contributor.authorWirtz, Maike
dc.contributor.authorKaiser, Rolf
dc.contributor.authorNorman, Betty
dc.contributor.authorOdame Phillips, Richard
dc.contributor.authorFeldt, Torsten
dc.contributor.authorEberhardt, Kirsten Alexandra
dc.date.accessioned2020-03-23T08:20:10Z
dc.date.available2020-03-23T08:20:10Z
dc.date.issued2020-02-16none
dc.identifier.other10.3390/v12020221
dc.identifier.urihttp://edoc.rki.de/176904/6548
dc.description.abstractIn the post-polio eradication era, increasing attention is given to non-polio enteroviruses. Most of the data about enteroviruses in sub-Saharan Africa are related to acute flaccid paralysis surveillance and target the pediatric population. This study aimed to investigate the presence of enterovirus in PLHIV (people living with HIV) and HIV-negative individuals in Ghana. Stool samples from HIV-positive individuals (n = 250) and healthy blood donors (n = 102) attending the Komfo Anokye Teaching Hospital in Kumasi, Ghana, were screened by real-time PCR for enterovirus. Molecular typing of the VP1 region was performed. Enterovirus-positive samples were tested for norovirus, adenovirus, rotavirus, sapovirus, and cosaviruses. Twenty-six out of 250 HIV-positive subjects (10.4%) and 14 out of 102 HIV-negative individuals (13.7%) were detected enterovirus-positive, not showing a significant different infection rate between the two groups. HIV-negative individuals were infected with Enterovirus C strains only. HIV-positive participants were detected positive for species Enterovirus A, Enterovirus B, and Enterovirus C. Co-infections with other viral enteric pathogens were almost exclusively detected among HIV-positive participants. Overall, the present study provides the first data about enteroviruses within HIV-positive and HIV-negative adults living in Ghana.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectenteroviruseng
dc.subjectHIVeng
dc.subjectGhanaeng
dc.subjectcosaviruseng
dc.subjectenteric infectioneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleMolecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghananone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6548-5
dc.identifier.doihttp://dx.doi.org/10.25646/6580
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirusesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/1999-4915/12/2/221none
local.edoc.container-publisher-nameMolecular Diversity Preservation International (MDPI)none
local.edoc.container-volume12none
local.edoc.container-issue2none
local.edoc.container-year2020none
local.edoc.container-firstpage1none
local.edoc.container-lastpage13none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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