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2019-11-29Zeitschriftenartikel DOI: 10.25646/6594
Meningitis gone viral: description of the echovirus wave 2013 in Germany
dc.contributor.authorGraf, Jonas
dc.contributor.authorHartmann, Christian J.
dc.contributor.authorLehmann, Helmar C.
dc.contributor.authorOtto, Carolin
dc.contributor.authorAdams, Ortwin
dc.contributor.authorKarenfort, Michael
dc.contributor.authorSchneider, Christian
dc.contributor.authorRuprecht, Klemens
dc.contributor.authorBosse, Hans Martin
dc.contributor.authorDiedrich, Sabine
dc.contributor.authorBöttcher, Sindy
dc.contributor.authorSchnitzler, Alfons
dc.contributor.authorHartung, Hans-Peter
dc.contributor.authorAktas, Orhan
dc.contributor.authorAlbrecht, Philipp
dc.date.accessioned2020-03-25T08:50:54Z
dc.date.available2020-03-25T08:50:54Z
dc.date.issued2019-11-29none
dc.identifier.other10.1186/s12879-019-4635-6
dc.identifier.urihttp://edoc.rki.de/176904/6556
dc.description.abstractBackground Aseptic meningitis epidemics may pose various health care challenges. Methods We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases. Results A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and 1 EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home. Conclusions Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectMeningitiseng
dc.subjectEchoviruseng
dc.subjectEpidemiceng
dc.subjectSurveillanceeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleMeningitis gone viral: description of the echovirus wave 2013 in Germanynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6556-0
dc.identifier.doihttp://dx.doi.org/10.25646/6594
dc.type.versionpublishedVersionnone
local.edoc.container-titleBMC Infectious Diseasesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-4635-6none
local.edoc.container-publisher-nameBioMed Centralnone
local.edoc.container-volume19none
local.edoc.container-issue1010none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage7none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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