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2019-12-03Zeitschriftenartikel DOI: 10.25646/6597
Age, maturation and serum lipid parameters: findings from the German Health Survey for Children and Adolescents
dc.contributor.authorSchienkiewitz, Anja
dc.contributor.authorTruthmann, Julia
dc.contributor.authorErnert, Andrea
dc.contributor.authorWiegand, Susanna
dc.contributor.authorSchwab, Karl Otfried
dc.contributor.authorScheidt-Nave, Christa
dc.date.accessioned2020-03-25T10:08:17Z
dc.date.available2020-03-25T10:08:17Z
dc.date.issued2019-12-03none
dc.identifier.other10.1186/s12889-019-7901-z
dc.identifier.urihttp://edoc.rki.de/176904/6559
dc.description.abstractBackground Recommendations on preventive lipid screening among children and adolescents remain controversial. The aim of the study was to assess age and puberty-related changes in serum lipids, including total cholesterol (TC), and high-density (HDL-C) and non-high-density lipoprotein cholesterol (Non-HDL-C). Methods Using cross-sectional data from the National Health Interview and Examination Survey for Children and Adolescents in Germany (KiGGS 2003–2006; N = 13,676; 1–17 years), changes in distributions of serum lipids were visualized according to sex, age and maturation. Youth aged 10–17 years were classified as prepubescent, early/mid-puberty, and mature/advanced puberty. Multiple linear regressions were used to quantify the impact of pubertal stage on serum lipid levels, adjusted for potential confounding factors. Results Among children 1–9 years mean serum lipid measures increased with age, with higher mean TC and Non-HDL-C among girls than boys. Among children 10–17 years, advanced pubertal stage was independently related to lower lipid measures. Adjusted mean TC, HDL-C and Non-HDL-C was 19.4, 5.9 and 13.6 mg/dL lower among mature/advanced puberty compared to prepubescent boys and 11.0, 4.0 and 7.0 mg/dL lower in mature/advanced puberty compared to prepubescent girls. Conclusions Lipid concentrations undergo considerable and sex-specific changes during physical growth and sexual maturation and significantly differ between pubertal stages. Screening recommendations need to consider the fluctuations of serum lipids during growth and sexual maturation.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectCholesteroleng
dc.subjectLipoproteineng
dc.subjectPopulation based studyeng
dc.subjectChildreneng
dc.subjectAdolescentseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleAge, maturation and serum lipid parameters: findings from the German Health Survey for Children and Adolescentsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6559-0
dc.identifier.doihttp://dx.doi.org/10.25646/6597
dc.type.versionpublishedVersionnone
local.edoc.container-titleBMC Public Healthnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7901-znone
local.edoc.container-publisher-nameBioMed Centralnone
local.edoc.container-volume19none
local.edoc.container-issue1627none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage14none
local.edoc.rki-departmentEpidemiologie und Gesundheitsmonitoringnone
dc.description.versionPeer Reviewednone

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