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2019-11-28Zeitschriftenartikel DOI: 10.25646/6606
Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
dc.contributor.authorKissling, Esther
dc.contributor.authorPozo, Francisco
dc.contributor.authorBuda, Silke
dc.contributor.authorVilcu, Ana-Maria
dc.contributor.authorGherasim, Alin
dc.contributor.authorBrytting, Mia
dc.contributor.authorDomegan, Lisa
dc.contributor.authorGómez, Verónica
dc.contributor.authorMeijer, Adam
dc.contributor.authorLazar, Mihaela
dc.contributor.authorVišekruna Vučina, Vesna
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorvan der Werf, Sylvie
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorEnkirch, Theresa
dc.contributor.authorO'Donnell, Joan
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorHooiveld, Mariëtte
dc.contributor.authorPetrović, Goranka
dc.contributor.authorStoian, Elena
dc.contributor.authorPenttinen, Pasi
dc.contributor.authorValenciano, Marta
dc.contributor.authorI-Move primary care study team
dc.date.accessioned2020-03-26T10:22:01Z
dc.date.available2020-03-26T10:22:01Z
dc.date.issued2019-11-28none
dc.identifier.other10.2807/1560-7917.ES.2019.24.48.1900604
dc.identifier.urihttp://edoc.rki.de/176904/6564
dc.description.abstractIntroduction Influenza A(H3N2) clades 3C.2a and 3C.3a co-circulated in Europe in 2018/19. Immunological imprinting by first childhood influenza infection may induce future birth cohort differences in vaccine effectiveness (VE). Aim The I-MOVE multicentre primary care test-negative study assessed 2018/19 influenza A(H3N2) VE by age and genetic subgroups to explore VE by birth cohort. Methods We measured VE against influenza A(H3N2) and (sub)clades. We stratified VE by usual age groups (0–14, 15–64, ≥ 65-years). To assess the imprint-regulated effect of vaccine (I-REV) hypothesis, we further stratified the middle-aged group, notably including 32–54-year-olds (1964–86) sharing potential childhood imprinting to serine at haemagglutinin position 159. Results Influenza A(H3N2) VE among all ages was −1% (95% confidence interval (CI): −24 to 18) and 46% (95% CI: 8–68), −26% (95% CI: −66 to 4) and 20% (95% CI: −20 to 46) among 0–14, 15–64 and ≥ 65-year-olds, respectively. Among 15–64-year-olds, VE against clades 3C.2a1b and 3C.3a was 15% (95% CI: −34 to 50) and −74% (95% CI: −259 to 16), respectively. VE was −18% (95% CI: −140 to 41), −53% (95% CI: −131 to −2) and −12% (95% CI: −74 to 28) among 15–31-year-olds (1987–2003), 32–54-year-olds (1964–86) and 55–64-year-olds (1954–63), respectively. Discussion The lowest 2018/19 influenza A(H3N2) VE was against clade 3C.3a and among those born 1964–86, corresponding to the I-REV hypothesis. The low influenza A(H3N2) VE in 15–64-year-olds and the public health impact of the I-REV hypothesis warrant further study.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectA(H3N2)eng
dc.subjectbirth cohortseng
dc.subjectimprintingeng
dc.subjectinfluenzaeng
dc.subjectmulticentre studyeng
dc.subjectvaccine effectivenesseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleLow 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohortnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6564-4
dc.identifier.doihttp://dx.doi.org/10.25646/6606
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.48.1900604#abstract_contentnone
local.edoc.container-publisher-nameInstitut de Veille Sanitairenone
local.edoc.container-volume24none
local.edoc.container-issue48none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage12none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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