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2020-03-24Zeitschriftenartikel DOI: 10.25646/6933
Specific circulating microRNAs during hepatitis E infection can serve as indicator for chronic hepatitis E
dc.contributor.authorHarms, Dominik
dc.contributor.authorChoi, Mira
dc.contributor.authorAllers, Kristina
dc.contributor.authorWang, Bo
dc.contributor.authorPietsch, Heiko
dc.contributor.authorPapp, C.-Patrick
dc.contributor.authorHanisch, Lina
dc.contributor.authorKurreck, Jens
dc.contributor.authorHofmann, Jörg
dc.contributor.authorBock, C.-Thomas
dc.date.accessioned2020-05-28T13:33:47Z
dc.date.available2020-05-28T13:33:47Z
dc.date.issued2020-03-24none
dc.identifier.other10.1038/s41598-020-62159-9
dc.identifier.urihttp://edoc.rki.de/176904/6819
dc.description.abstractHepatitis E virus (HEV) genotypes 3 and 4 (HEV-3, HEV-4) infections are an emerging public health issue in industrialized countries. HEV-3 and −4 are usually self-limiting but can progress to chronic hepatitis E in immunocompromised individuals. The molecular mechanisms involved in persistent infections are poorly understood. Micro RNAs (miRNAs) can regulate viral pathogenesis and can serve as novel disease biomarkers. We aimed to explore the modulation of serum miRNAs in patients with acute (AHE) and chronic (CHE) hepatitis E. Both AHE- and CHE-patients exhibited high viral loads (median 3.23E + 05 IU/mL and 2.11E + 06 IU/mL, respectively) with HEV-3c being the predominant HEV-genotype. Expression analysis of liver-specific serum miRNAs was performed using real-time PCR. miR-99a-5p, miR-122-5p, and miR-125b-5p were upregulated in AHE (4.70–5.28 fold) and CHE patients (2.28–6.34 fold), compared to HEV-negative controls. Notably, miR-192-5p was increased 2.57 fold while miR-125b-5p was decreased 0.35 fold in CHE but not in AHE patients. Furthermore, decreased miR-122-5p expression significantly correlates with reduced liver transaminases in CHE patients. To our knowledge, this marks the first investigation concerning the regulation of circulating liver-specific miRNAs in acute and chronic HEV infections. We found that miR-125b-5p, miR-192-5p, and miR-99a-5p may prove useful in the diagnosis of chronic hepatitis E.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectMicrobiologyeng
dc.subjectViral host responseeng
dc.subjectVirologyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSpecific circulating microRNAs during hepatitis E infection can serve as indicator for chronic hepatitis Enone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6819-4
dc.identifier.doihttp://dx.doi.org/10.25646/6933
dc.type.versionpublishedVersionnone
local.edoc.container-titleScientific Reportsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41598-020-62159-9none
local.edoc.container-publisher-nameNaturenone
local.edoc.container-volume10none
local.edoc.container-issue5337none
local.edoc.container-year2020none
local.edoc.container-firstpage1none
local.edoc.container-lastpage10none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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