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2009-07-01Zeitschriftenartikel DOI: 10.1128/JCM.00648-09
Emergence of a community-associated methicillin-resistant Staphylococcus aureus with unique resistance profile in Southwest of Nigeria
dc.contributor.authorGhebremedhin, B.
dc.contributor.authorOlugbosi, M. O.
dc.contributor.authorRaji, A. M.
dc.contributor.authorLayer, Franziska
dc.contributor.authorBakare, R. A.
dc.contributor.authorKönig, B.
dc.contributor.authorKönig, Wolfgang
dc.date.accessioned2018-05-07T14:10:36Z
dc.date.available2018-05-07T14:10:36Z
dc.date.created2010-11-15
dc.date.issued2009-07-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/regeyC1JYVw/PDF/244Iu2YhTpjqs.pdf
dc.identifier.urihttp://edoc.rki.de/176904/736
dc.description.abstractPheno-, genotypic and toxin gene analysis has not been done yet all in one for Nigerian Staphylococcus aureus population. This study provides a comprehensive overview on the molecular epidemiology and genetic diversity of S. aureus at the largest university clinic in Ibadan, Nigeria. At the University Teaching Hospital in Ibadan, Nigeria, out of 1300 patients' clinical samples 346 non-duplicate S. aureus isolates were obtained during the 1-year-surveillance in 2007. All isolates underwent antibiotic susceptibility testing, toxin gene analysis, MLST (multilocus sequence typing), agr group and spa typing. And for MRSA SCCmec typing was performed. 20.23% of the 346 isolates were methicillin-resistant. 33 patients' isolates (47.15%) fulfilled the definition criteria for CA-MRSA according to the review of the medical charts. The majority of MRSA strains analyzed were isolated from surgical and paediatric patients. The commonest types of infection identified with MRSA were surgical site infections (>70%) whereas for CA-MRSA were conjunctivitis and otitis in 19 patients (57.6%) and accidental skin and subcutaneous tissue infection in 14 patients (42.4 %). The MSSA strains (ST1, ST5, ST15, ST7, ST8, ST25, ST30, ST72, ST80, ST121 and ST508) were heterogeneous by pheno- and genotypic analysis. The first report and genetic analyses of PVL-positive ST88 strain (agr III, SCCmec IV) in Nigeria is shown in this study. ST88 was resistant to trimethoprim-sulfamethoxazole besides to penicillin and oxacillin. CA-MRSA infections are rapidly increasing among young patients with ophthalmologic and auricular infections. Urban regions of lower socioeconomic status and evidence of overcrowding appear to be at higher risk for the emergence of this clone.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAdolescenteng
dc.subjectPreschooleng
dc.subjectDNAeng
dc.subjectHumanseng
dc.subjectGenotypeeng
dc.subjectHospitalseng
dc.subjectCluster Analysiseng
dc.subjectMiddle Agedeng
dc.subjectNigeria/epidemiologyeng
dc.subjectChildeng
dc.subjectAdulteng
dc.subjectSequence Analysiseng
dc.subjectGenetic Variationeng
dc.subjectMicrobial Sensitivity Testseng
dc.subjectYoung Adulteng
dc.subjectBacterial Typing Techniqueseng
dc.subjectAnti-Bacterial Agents/pharmacologyeng
dc.subjectMolecular Epidemiologyeng
dc.subjectDNA Fingerprintingeng
dc.subjectBacterial Toxins/geneticseng
dc.subjectCommunity-Acquired Infections/epidemiologyeng
dc.subjectCommunity-Acquired Infections/microbiologyeng
dc.subjectConjunctivitis/microbiologyeng
dc.subjectMethicillin-Resistant Staphylococcus aureus/classificationeng
dc.subjectMethicillin-Resistant Staphylococcus aureus/isolation & purificationeng
dc.subjectOtitis/microbiologyeng
dc.subjectSoft Tissue Infections/microbiologyeng
dc.subjectStaphylococcal Infections/epidemiologyeng
dc.subjectStaphylococcal Infections/microbiologyeng
dc.subjectStaphylococcal Skin Infections/microbiologyeng
dc.subjectSurgical Wound Infection/microbiologyeng
dc.subjectUrban Populationeng
dc.subject.ddc610 Medizin
dc.titleEmergence of a community-associated methicillin-resistant Staphylococcus aureus with unique resistance profile in Southwest of Nigeria
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10011338
dc.identifier.doi10.1128/JCM.00648-09
dc.identifier.doihttp://dx.doi.org/10.25646/661
local.edoc.container-titleJournal of Clinical Microbiology
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jcm.asm.org/cgi/content/abstract/JCM.00648-09v1
local.edoc.container-publisher-nameAmerican Society for Microbiology
local.edoc.container-year2009

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