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2009-11-18Zeitschriftenartikel DOI: 10.1099/vir.0.017251-0
Lymphocryptovirus phylogeny and the origins of Epstein-Barr virus.
dc.contributor.authorEhlers, Bernhard
dc.contributor.authorSpieß, Katja
dc.contributor.authorLeendertz, Fabian
dc.contributor.authorPeeters, Martine
dc.contributor.authorBoesch, Christophe
dc.contributor.authorGatherer, Derek
dc.contributor.authorMcGeoch, Duncan J.
dc.date.accessioned2018-05-07T14:12:41Z
dc.date.available2018-05-07T14:12:41Z
dc.date.created2010-11-18
dc.date.issued2009-11-18none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reyW1vTjDkJX6/PDF/25QYC2e1bCXuk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/747
dc.description.abstractSpecimens from wild and captive primates were collected, and searched for new members of the genus Lymphocryptovirus (subfamily Gammaherpesvirinae) utilising PCR for the DNA polymerase gene. Twenty-one new viruses were detected. Together with previous findings, more than 50 distinct lymphocryptoviruses (LCVs) are now known, with hosts from six primate families (Hominidae, Hylobatidae, Cercopithecidae, Atelidae, Cebidae, Pitheciidae). Further work extended genomic sequences for 25 LCVs to 3.4-7.4 kbp. Phylogenetic trees were constructed, based on alignments of protein sequences inferred from the LCV genomic data. The LCVs fell into three major clades: Clade A, comprising New World viruses; Clade B, containing both Old World monkey viruses and hominoid viruses including Epstein-Barr virus (EBV); and Clade C, containing other hominoid viruses. By comparison with the primate tree, it was proposed that major elements of the LCV tree represented synchronous evolution with host lineages, with the earliest node in both trees being separation of Old and New World lines, but that some virus lineages originated by interspecies transfer. From comparisons of branch lengths, it was inferred that evolutionary substitution in Clade B has proceeded more slowly than elsewhere in the LCV tree. It was estimated that in Clade B a subclade containing EBV, a gorilla virus and two chimpanzee viruses derived from an Old World monkey LCV line approximately twelve million years ago, and another subclade containing an orang utan virus and a gibbon virus derived from a macaque LCV line approximately 1.2 million years ago.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAnimalseng
dc.subjectMoleculareng
dc.subjectDNAeng
dc.subjectPhylogenyeng
dc.subjectSequence Homologyeng
dc.subjectAmino Acideng
dc.subjectCluster Analysiseng
dc.subjectViral/geneticseng
dc.subjectSequence Analysiseng
dc.subjectViral Proteins/geneticseng
dc.subjectPolymerase Chain Reaction/methodseng
dc.subjectDNA-Directed DNA Polymerase/geneticseng
dc.subjectEvolutioneng
dc.subjectLymphocryptovirus/geneticseng
dc.subjectPrimates/virologyeng
dc.subject.ddc610 Medizin
dc.titleLymphocryptovirus phylogeny and the origins of Epstein-Barr virus.
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10011461
dc.identifier.doi10.1099/vir.0.017251-0
dc.identifier.doihttp://dx.doi.org/10.25646/672
local.edoc.container-titleJournal of General Virology
local.edoc.container-textThis is an author manuscript that has been accepted for publication in Microbiology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in Microbiology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of ‘Fair Use of Copyrighted Materials’ (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://mic.sgmjournals.org, and is freely available without a subscription 12 months after publication.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://vir.sgmjournals.org/cgi/content/abstract/vir.0.017251-0v1
local.edoc.container-publisher-nameSociety for General Microbiology
local.edoc.container-volume91
local.edoc.container-issue3
local.edoc.container-year2010

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