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2021-01-01Zeitschriftenartikel DOI: 10.25646/7905
Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors
dc.contributor.authorNie, Chuanxiong
dc.contributor.authorStadtmüller, Marlena
dc.contributor.authorParshad, Badri
dc.contributor.authorWallert, Matthias
dc.contributor.authorAhmadi, Vahid
dc.contributor.authorKerkhoff, Yannic
dc.contributor.authorBhatia, Sumati
dc.contributor.authorBlock, Stephan
dc.contributor.authorCheng, Chong
dc.contributor.authorWolff, Thorsten
dc.contributor.authorHaag, Rainer
dc.date.accessioned2021-01-23T13:25:13Z
dc.date.available2021-01-23T13:25:13Z
dc.date.issued2021-01-01none
dc.identifier.other10.1126/sciadv.abd3803
dc.identifier.urihttp://edoc.rki.de/176904/7694
dc.description.abstractHere, we report the topology-matched design of heteromultivalent nanostructures as potent and broad-spectrum virus entry inhibitors based on the host cell membrane. Initially, we investigate the virus binding dynamics to validate the better binding performance of the heteromultivalent moieties as compared to homomultivalent ones. The heteromultivalent binding moieties are transferred to nanostructures with a bowl-like shape matching the viral spherical surface. Unlike the conventional homomultivalent inhibitors, the heteromultivalent ones exhibit a half maximal inhibitory concentration of 32.4 ± 13.7 μg/ml due to the synergistic multivalent effects and the topology-matched shape. At a dose without causing cellular toxicity, >99.99% reduction of virus propagation has been achieved. Since multiple binding sites have also been identified on the S protein of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), we envision that the use of heteromultivalent nanostructures may also be applied to develop a potent inhibitor to prevent coronavirus infection.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC 3.0 DE) Namensnennung - Nicht kommerziell 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHeteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitorsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/7694-5
dc.identifier.doihttp://dx.doi.org/10.25646/7905
dc.type.versionpublishedVersionnone
local.edoc.container-titleScienceAdvancesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://advances.sciencemag.org/content/7/1/eabd3803none
local.edoc.container-publisher-nameAmerican Association for the Advancement of Sciencenone
local.edoc.container-volume7none
local.edoc.container-issue1none
local.edoc.container-reportyear2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage10none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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