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2021-02-03Zeitschriftenartikel DOI: 10.1038/s41467-021-21012-x
A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone
dc.contributor.authorOwens, Leah A.
dc.contributor.authorColitti, Barbara
dc.contributor.authorHirji, Ismail
dc.contributor.authorPizarro, Andrea
dc.contributor.authorJaffe, Jenny E.
dc.contributor.authorMoittié, Sophie
dc.contributor.authorBishop-Lilly, Kimberly A.
dc.contributor.authorEstrella, Luis A.
dc.contributor.authorVoegtly, Logan J.
dc.contributor.authorKuhn, Jens H.
dc.contributor.authorSuen, Garret
dc.contributor.authorDeblois, Courtney L.
dc.contributor.authorDunn, Christopher D.
dc.contributor.authorJuan-Sallés, Carles
dc.contributor.authorGoldberg, Tony L.
dc.date.accessioned2021-03-02T08:58:53Z
dc.date.available2021-03-02T08:58:53Z
dc.date.issued2021-02-03none
dc.identifier.other10.1038/s41467-021-21012-x
dc.identifier.urihttp://edoc.rki.de/176904/7861
dc.description.abstractHuman and animal infections with bacteria of the genus Sarcina (family Clostridiaceae) are associated with gastric dilation and emphysematous gastritis. However, the potential roles of sarcinae as commensals or pathogens remain unclear. Here, we investigate a lethal disease of unknown etiology that affects sanctuary chimpanzees (Pan troglodytes verus) in Sierra Leone. The disease, which we have named “epizootic neurologic and gastroenteric syndrome” (ENGS), is characterized by neurologic and gastrointestinal signs and results in death of the animals, even after medical treatment. Using a case-control study design, we show that ENGS is strongly associated with Sarcina infection. The microorganism is distinct from Sarcina ventriculi and other known members of its genus, based on bacterial morphology and growth characteristics. Whole-genome sequencing confirms this distinction and reveals the presence of genetic features that may account for the unusual virulence of the bacterium. Therefore, we propose that this organism be considered the representative of a new species, named “Candidatus Sarcina troglodytae”. Our results suggest that a heretofore unrecognized complex of related sarcinae likely exists, some of which may be highly virulent. However, the potential role of “Ca. S. troglodytae” in the etiology of ENGS, alone or in combination with other factors, remains a topic for future research.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectClinical microbiologyeng
dc.subjectInfectious-disease epidemiologyeng
dc.subjectPathogenseng
dc.subjectInfectioneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleA Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leonenone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/7861-8
dc.identifier.doihttps://doi.org/10.1038/s41467-021-21012-x
dc.identifier.doihttp://dx.doi.org/10.25646/8097
dc.type.versionpublishedVersionnone
local.edoc.container-titleNature Communicationsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/articles/s41467-021-21012-xnone
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume763none
local.edoc.container-issue12none
local.edoc.container-reportyear2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage16none
local.edoc.rki-departmentInstitutsleitungnone
dc.description.versionPeer Reviewednone

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