Phylogenetic and case-control study on hepatitis E virus infection in Germany
dc.contributor.author | Wichmann, Ole | |
dc.contributor.author | Schimanski, Sven | |
dc.contributor.author | Koch, Judith | |
dc.contributor.author | Kohler, Martin | |
dc.contributor.author | Rothe, Camilla | |
dc.contributor.author | Plentz, Annelie | |
dc.contributor.author | Jilg, Wolfgang | |
dc.contributor.author | Stark, Klaus | |
dc.date.accessioned | 2018-05-07T14:20:24Z | |
dc.date.available | 2018-05-07T14:20:24Z | |
dc.date.created | 2011-01-18 | |
dc.date.issued | 2008-12-15 | none |
dc.identifier.other | http://edoc.rki.de/oa/articles/rensDqZH1Qe2/PDF/25Lg42SL1pZHU.pdf | |
dc.identifier.uri | http://edoc.rki.de/176904/788 | |
dc.description.abstract | Background: Hepatitis E is a classic water-borne disease in developing countries. In Germany, hepatitis E virus (HEV) infections are notifiable. The number of non–travel-associated infections has increased in recent years, but the route of transmission in most is unknown. Our objective was to determine risk factors for autochthonous HEV infections in Germany. Methods: Cases of HEV met clinical definitions and were confirmed by laboratory analysis (defined as detection of HEV by polymerase chain reaction [PCR] or immunoglobulinMby serologic testing). PCR products from blood or stool samples were genotyped for phylogenetic analysis. A case-control study included case subjects with autochthonous HEV infection and matched control subjects who were randomly recruited from a population-based telephone list. Results: From May 2006 through August 2007, 76 of 96 persons for whom HEV infection had been reported to the routine surveillance system were interviewed. Sixty-six persons had disease that fulfilled the inclusion criteria: 45 (68%) had autochthonous infection, and 21 (32%) had travel-associated disease. Genotypes 3 or 4 were present in 15 of 15 persons with autochthonous infection, and genotype 1 was present in 8 of 9 persons with travel-associated infection. In conditional logistic regression involving 45 case subjects and 135 control subjects, consumption of offal (41% vs. 19%; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.2– 6.2) and wild-boar meat (20% vs. 7%; OR, 4.3; 95% CI, 1.2–15.9) were independently associated with autochthonous HEV infection. Conclusion: Hepatitis E is endemic in Germany and likely exists as a food-borne zoonosis. Implicated meat products should be investigated to provide recommendations for preventive measures. | eng |
dc.language.iso | eng | |
dc.publisher | Robert Koch-Institut, Infektionsepidemiologie | |
dc.subject | Adolescent | eng |
dc.subject | Humans | eng |
dc.subject | Phylogeny | eng |
dc.subject | Female | eng |
dc.subject | Genotype | eng |
dc.subject | Travel | eng |
dc.subject | Germany/epidemiology | eng |
dc.subject | Male | eng |
dc.subject | Middle Aged | eng |
dc.subject | Risk Factors | eng |
dc.subject | Child | eng |
dc.subject | Adult | eng |
dc.subject | Case-Control Studies | eng |
dc.subject | Aged | eng |
dc.subject | Young Adult | eng |
dc.subject | Hepatitis E/epidemiology | eng |
dc.subject | Hepatitis E/genetics | eng |
dc.subject | Hepatitis E virus/genetics | eng |
dc.subject | Aged 80 and over | eng |
dc.subject.ddc | 610 Medizin | |
dc.title | Phylogenetic and case-control study on hepatitis E virus infection in Germany | |
dc.type | periodicalPart | |
dc.identifier.urn | urn:nbn:de:0257-10012113 | |
dc.identifier.doi | 10.1086/593211 | |
dc.identifier.doi | http://dx.doi.org/10.25646/713 | |
local.edoc.container-title | Journal of Infectious Diseases | |
local.edoc.container-text | Wichmann, O., Schimanski, S., Koch, J., Kohler, M., Rothe, C., Plentz, A., Jilg, W., Stark, K. Phylogenetic and case-control study on hepatitis E virus infection in Germany (2008) Journal of Infectious Diseases, 198 (12), pp. 1732-1741. | |
local.edoc.fp-subtype | Artikel | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | http://jid.oxfordjournals.org/content/198/12/1732.long | |
local.edoc.container-publisher-name | University of Chicago Press | |
local.edoc.container-volume | 198 | |
local.edoc.container-issue | 12 | |
local.edoc.container-year | 2008 |