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2008-12-15Zeitschriftenartikel DOI: 10.1086/593211
Phylogenetic and case-control study on hepatitis E virus infection in Germany
dc.contributor.authorWichmann, Ole
dc.contributor.authorSchimanski, Sven
dc.contributor.authorKoch, Judith
dc.contributor.authorKohler, Martin
dc.contributor.authorRothe, Camilla
dc.contributor.authorPlentz, Annelie
dc.contributor.authorJilg, Wolfgang
dc.contributor.authorStark, Klaus
dc.date.accessioned2018-05-07T14:20:24Z
dc.date.available2018-05-07T14:20:24Z
dc.date.created2011-01-18
dc.date.issued2008-12-15none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rensDqZH1Qe2/PDF/25Lg42SL1pZHU.pdf
dc.identifier.urihttp://edoc.rki.de/176904/788
dc.description.abstractBackground: Hepatitis E is a classic water-borne disease in developing countries. In Germany, hepatitis E virus (HEV) infections are notifiable. The number of non–travel-associated infections has increased in recent years, but the route of transmission in most is unknown. Our objective was to determine risk factors for autochthonous HEV infections in Germany. Methods: Cases of HEV met clinical definitions and were confirmed by laboratory analysis (defined as detection of HEV by polymerase chain reaction [PCR] or immunoglobulinMby serologic testing). PCR products from blood or stool samples were genotyped for phylogenetic analysis. A case-control study included case subjects with autochthonous HEV infection and matched control subjects who were randomly recruited from a population-based telephone list. Results: From May 2006 through August 2007, 76 of 96 persons for whom HEV infection had been reported to the routine surveillance system were interviewed. Sixty-six persons had disease that fulfilled the inclusion criteria: 45 (68%) had autochthonous infection, and 21 (32%) had travel-associated disease. Genotypes 3 or 4 were present in 15 of 15 persons with autochthonous infection, and genotype 1 was present in 8 of 9 persons with travel-associated infection. In conditional logistic regression involving 45 case subjects and 135 control subjects, consumption of offal (41% vs. 19%; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.2– 6.2) and wild-boar meat (20% vs. 7%; OR, 4.3; 95% CI, 1.2–15.9) were independently associated with autochthonous HEV infection. Conclusion: Hepatitis E is endemic in Germany and likely exists as a food-borne zoonosis. Implicated meat products should be investigated to provide recommendations for preventive measures.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectAdolescenteng
dc.subjectHumanseng
dc.subjectPhylogenyeng
dc.subjectFemaleeng
dc.subjectGenotypeeng
dc.subjectTraveleng
dc.subjectGermany/epidemiologyeng
dc.subjectMaleeng
dc.subjectMiddle Agedeng
dc.subjectRisk Factorseng
dc.subjectChildeng
dc.subjectAdulteng
dc.subjectCase-Control Studieseng
dc.subjectAgedeng
dc.subjectYoung Adulteng
dc.subjectHepatitis E/epidemiologyeng
dc.subjectHepatitis E/geneticseng
dc.subjectHepatitis E virus/geneticseng
dc.subjectAged 80 and overeng
dc.subject.ddc610 Medizin
dc.titlePhylogenetic and case-control study on hepatitis E virus infection in Germany
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10012113
dc.identifier.doi10.1086/593211
dc.identifier.doihttp://dx.doi.org/10.25646/713
local.edoc.container-titleJournal of Infectious Diseases
local.edoc.container-textWichmann, O., Schimanski, S., Koch, J., Kohler, M., Rothe, C., Plentz, A., Jilg, W., Stark, K. Phylogenetic and case-control study on hepatitis E virus infection in Germany (2008) Journal of Infectious Diseases, 198 (12), pp. 1732-1741.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jid.oxfordjournals.org/content/198/12/1732.long
local.edoc.container-publisher-nameUniversity of Chicago Press
local.edoc.container-volume198
local.edoc.container-issue12
local.edoc.container-year2008

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