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2010-05-03Zeitschriftenartikel DOI: 10.1093/aje/kwq071
Shedding and Transmission of Novel Influenza Virus A/H1N1 Infection in Households—Germany, 2009
dc.contributor.authorSüß, Thorsten
dc.contributor.authorBuchholz, Udo
dc.contributor.authorDupke, Susann
dc.contributor.authorGrunow, Roland
dc.contributor.authorHeiden, Matthias an der
dc.contributor.authorHeider, Alla
dc.contributor.authorBiere, Barbara
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorHaas, Walter
dc.contributor.authorKrause, Gérard
dc.date.accessioned2018-05-07T14:36:25Z
dc.date.available2018-05-07T14:36:25Z
dc.date.created2011-05-17
dc.date.issued2010-05-03none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rewqO2NVJ26c/PDF/25QaJ3VkxiUrw.pdf
dc.identifier.urihttp://edoc.rki.de/176904/875
dc.description.abstractEssential epidemiologic and virologic parameters must be measured to provide evidence for policy/public health recommendations and mathematical modeling concerning novel influenza A/H1N1 virus (NIV) infections. Therefore, from April through August of 2009, the authors collected nasopharyngeal specimens and information on antiviral medication and symptoms from households with NIV infection on a daily basis in Germany. Specimens were analyzed quantitatively by using reverse transcriptase-polymerase chain reaction. In 36 households with 83 household contacts, 15 household contacts became laboratory-confirmed secondary cases of NIV. Among 47 contacts without antiviral prophylaxis, 12 became cases (secondary attack rate of 26%), and 1 (8%) of these was asymptomatic. The mean and median serial interval were 2.6 and 3 days, respectively (range: 1-3 days). On average, the authors detected viral RNA copies for 6.6 illness days (treated in time = 5.7 days, not treated in time = 7.1 days; P = 0.06), but they estimated that most patients cease to excrete viable virus by the fifth illness day. Shedding profiles were consistent with the number and severity of symptoms. Compared with other nasopharyngeal specimen types, nasal wash was the most sensitive. These results support the notion that epidemiologic and virologic characteristics of NIV are in many aspects similar to those of seasonal influenza.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectdisease transmissioneng
dc.subjectinfectiouseng
dc.subjectinfluenza A viruseng
dc.subjectH1N1 subtypeeng
dc.subjectOrthomyxoviridaeeng
dc.subjectsensitivity and specificityeng
dc.subjectvirus sheddingeng
dc.subject.ddc610 Medizin
dc.titleShedding and Transmission of Novel Influenza Virus A/H1N1 Infection in Households—Germany, 2009
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10014224
dc.identifier.doi10.1093/aje/kwq071
dc.identifier.doihttp://dx.doi.org/10.25646/800
local.edoc.container-titleAmerican Journal of Epidemiology
local.edoc.container-textSuess, T., Buchholz, U., Dupke, S., Grunow, R., Der Heiden, M.A., Heider, A., Biere, B., Schweiger, B., Haas, W., Krause, G. Shedding and transmission of novel influenza virus A/H1N1 infection in households-Germany, 2009 (2010) American Journal of Epidemiology, 171 (11), pp. 1157-1164.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://aje.oxfordjournals.org/content/171/11/1157.abstract#cited-by
local.edoc.container-publisher-nameOxford University Press
local.edoc.container-volume171
local.edoc.container-issue11
local.edoc.container-year2010

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