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2021-06-24Zeitschriftenartikel DOI: 10.25646/9348
Primary and pollen-associated hazelnut allergy in school-aged children in Germany: A birth cohort study
dc.contributor.authorErhard, Sina M.
dc.contributor.authorBellach, Johanna
dc.contributor.authorYürek, Songül
dc.contributor.authorTschirner, Sebastian
dc.contributor.authorTrendelenburg, Valérie
dc.contributor.authorGrabenhenrich, Linus B.
dc.contributor.authorFernandez-Rivas, Montserrat
dc.contributor.authorvan Ree, Ronald
dc.contributor.authorKeil, Thomas
dc.contributor.authorBeyer, Kirsten
dc.date.accessioned2021-12-03T12:09:31Z
dc.date.available2021-12-03T12:09:31Z
dc.date.issued2021-06-24none
dc.identifier.other10.1016/j.alit.2021.05.006
dc.identifier.urihttp://edoc.rki.de/176904/9054
dc.description.abstractBackground: Primary hazelnut allergy is a common cause of anaphylaxis in children, as compared to birch-pollen associated hazelnut allergy. Population-based data on hazelnut and concomitant birch-pollen allergy in children are lacking. We aimed to investigate the prevalence of primary and pollen-associated hazelnut allergy and sensitization profiles in school-aged children in Berlin, Germany. Methods: 1570 newborn children were recruited in Berlin in 2005–2009. The school-age follow-up (2014–2017) was based on a standardized web-based parental questionnaire and clinical evaluation by a physician including skin prick tests, allergen specific immunoglobulin E serum tests and placebo-controlled double-blind oral food challenges, if indicated. Results: 1004 children (63.9% response) participated in the school-age follow-up assessment (52.1% male). For 1.9% (n = 19, 95%-confidence interval 1.1%–2.9%) of children their parents reported hazelnut-allergic symptoms, for half of these to roasted hazelnut indicating primary hazelnut allergy. Symptoms of birch-pollen allergy were reported for 11.6% (n = 116 95%-CI 9.7%–13.7%) of the children. Both birch-pollen allergy and hazelnut allergy associated symptoms affected 0.6% (n = 6, 95%-CI 0.2%–1.3%) of children. Assessment of allergic sensitization was performed in 261 participants and showed that almost 20% of these children were sensitized to hazelnut, being the most frequent of all assessed food allergens, or birch-pollen, the majority to both. Conclusions: Based on parental reports hazelnut-allergic symptoms were far less common than sensitization to hazelnut. This needs to be considered by physicians to avoid unnecessary changes in diet due to sensitization profiles only, especially when there is a co-sensitization to hazelnut and birch-pollen.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectBirch-polleneng
dc.subjectEpidemiologyeng
dc.subjectFood allergyeng
dc.subjectHazelnuteng
dc.subjectSeasonal allergic rhinitiseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePrimary and pollen-associated hazelnut allergy in school-aged children in Germany: A birth cohort studynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9054-5
dc.identifier.doihttp://dx.doi.org/10.25646/9348
dc.type.versionpublishedVersionnone
local.edoc.container-titleAllergology Internationalnone
local.edoc.container-issn1440-1592none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/science/article/pii/S1323893021000575?via%3Dihubnone
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume70none
local.edoc.container-issue4none
local.edoc.container-year2021none
local.edoc.container-firstpage463none
local.edoc.container-lastpage470none
dc.description.versionPeer Reviewednone

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