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2021-10-29Zeitschriftenartikel DOI: 10.25646/9496
Tolerance and Persistence of Ebola Virus in Primary Cells from Mops condylurus, a Potential Ebola Virus Reservoir
dc.contributor.authorBokelmann, Marcel
dc.contributor.authorVogel, Uwe
dc.contributor.authorDebeljak, Franka
dc.contributor.authorDüx, Ariane
dc.contributor.authorRiesle-Sbarbaro, Silke
dc.contributor.authorLander, Angelika
dc.contributor.authorWahlbrink, Annette
dc.contributor.authorKromarek, Nicole
dc.contributor.authorNeil, Stuart
dc.contributor.authorCouacy-Hymann, Emmanuel
dc.contributor.authorPrescott, Joseph
dc.contributor.authorKurth, Andreas
dc.date.accessioned2022-01-04T07:47:21Z
dc.date.available2022-01-04T07:47:21Z
dc.date.issued2021-10-29none
dc.identifier.other10.3390/v13112186
dc.identifier.urihttp://edoc.rki.de/176904/9205
dc.description.abstractAlthough there have been documented Ebola virus disease outbreaks for more than 40 years, the natural reservoir host has not been identified. Recent studies provide evidence that the Angolan free-tailed bat (Mops condylurus), an insectivorous microbat, is a possible ebolavirus reservoir. To investigate the potential role of this bat species in the ecology of ebolaviruses, replication, tolerance, and persistence of Ebola virus (EBOV) were investigated in 10 different primary bat cell isolates from M. condylurus. Varying EBOV replication kinetics corresponded to the expression levels of the integral membrane protein NPC1. All primary cells were highly tolerant to EBOV infection without cytopathic effects. The observed persistent EBOV infection for 150 days in lung primary cells, without resultant selective pressure leading to virus mutation, indicate the intrinsic ability of EBOV to persist in this bat species. These results provide further evidence for this bat species to be a likely reservoir of ebolaviruses.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectEbola viruseng
dc.subjectreservoir hosteng
dc.subjectbateng
dc.subjectvirus replicationeng
dc.subjecttoleranceeng
dc.subjectpersistent infectioneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleTolerance and Persistence of Ebola Virus in Primary Cells from Mops condylurus, a Potential Ebola Virus Reservoirnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9205-6
dc.identifier.doihttp://dx.doi.org/10.25646/9496
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirusesnone
local.edoc.container-issn1999-4915none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/1999-4915/13/11/2186none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume13none
local.edoc.container-issue11none
local.edoc.container-year2021none
dc.description.versionPeer Reviewednone

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