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2010-06-30Zeitschriftenartikel DOI: 10.1111/j.1863-2378.2010.01342.x
Confirmed Exposure to Tick-Borne Encephalitis Virus and Probable Human Cases of Tick-Borne Encephalitis in Central/Northern Anatolia, Turkey
dc.contributor.authorErgünay, Koray
dc.contributor.authorSaygan, Mehmet B.
dc.contributor.authorAydoğan, Sibel
dc.contributor.authorLitzba, Nadine
dc.contributor.authorSener, B.
dc.contributor.authorLederer, Sabine
dc.contributor.authorNiedrig, Matthias
dc.contributor.authorHasçelik, G.
dc.contributor.authorUs, Dürdal
dc.date.accessioned2018-05-07T14:44:47Z
dc.date.available2018-05-07T14:44:47Z
dc.date.created2011-08-29
dc.date.issued2010-06-30none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reC8awwIxZN3M/PDF/27YEIo01GPAmk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/920
dc.description.abstractTick-borne encephalitis virus (TBEV) is the aetiological agent of tick-borne encephalitis (TBE), a potentially fatal central nervous system infection of humans. TBE is endemic in many areas of Europe and Asia; however, very scarce data on TBEV activity are available from Turkey. We aimed to identify TBEV exposure in healthy blood donors and the impact of TBEV in central nervous system infections in Central/Northern Anatolia. Two-thousand four hundred and fifty four sera, collected from blood donors at Ankara, Konya, Eskişehir and Zonguldak branches of the Turkish Red Crescent Middle Anatolia Regional Blood Center, were analysed for TBEV serosurveillance. Paired serum and cerebrospinal fluid samples from 108 patients with the diagnosis of aseptic meningitis/encephalitis of unknown aetiology were also evaluated to identify TBE and neuroborreliosis cases. Commercial enzyme-linked immunosorbent assays and indirect immunofluorescence tests were employed for antibody detection. Forty-seven donor samples (1.9%) were reactive for TBEV IgG. In 25 persons with IgG reactivity (53.1%), risk factors for tick-borne infections were revealed. One sample from Zonguldak province (1/198; 0.5%) in the Black Sea region of Turkey was confirmed to possess neutralizing antibodies via plaque reduction neutralization test. TBEV IgM was detected in 9.2% (8/108) of the patients. IgM was accompanied by IgG reactivity in two persons where, in one, recent history of a tick bite was also identified. Intrathecal antibody production for TBEV could not be demonstrated. No evidence for Borrelia infections could be found. Confirmed exposure to TBEV and/or an antigenically similar tick-borne flavivirus is documented for the first time in blood donors in Zonguldak in Northern Anatolia. Probable cases of TBE have also been identified from Central Anatolia. The epidemiology of TBEV activity in Turkey needs to be assessed and benefits of vaccination for general population, risk groups or travellers must be considered.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjectTick-borne encephalitiseng
dc.subjectTBEeng
dc.subjecttick-borne encephalitis viruseng
dc.subjectTBEVeng
dc.subjectAnatoliaeng
dc.subjectTurkeyeng
dc.subject.ddc610 Medizin
dc.titleConfirmed Exposure to Tick-Borne Encephalitis Virus and Probable Human Cases of Tick-Borne Encephalitis in Central/Northern Anatolia, Turkey
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10015035
dc.identifier.doi10.1111/j.1863-2378.2010.01342.x
dc.identifier.doihttp://dx.doi.org/10.25646/845
local.edoc.container-titleZoonoses and Public Health
local.edoc.container-textErgünay, K., Saygan, M.B., Aydoǧan, S., Litzba, N., Şener, B., Lederer, S., Niedrig, M., Hasçelik, G., Us, D. Confirmed Exposure to Tick-Borne Encephalitis Virus and Probable Human Cases of Tick-Borne Encephalitis in Central/Northern Anatolia, Turkey (2011) Zoonoses and Public Health, 58 (3), pp. 220-227.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1863-2378.2010.01342.x/abstract
local.edoc.container-publisher-nameWiley
local.edoc.container-volume58
local.edoc.container-issue3
local.edoc.container-year2011

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