Show simple item record

2021-03-24Zeitschriftenartikel
Genetic Diversity of Enteric Viruses in Children under Five Years Old in Gabon
dc.contributor.authorManouana, Gédéon Prince
dc.contributor.authorNguema-Moure, Paul Alvyn
dc.contributor.authorNgwese, Mirabeau Mbong
dc.contributor.authorBock, C.-Thomas
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorBorrmann, Steffen
dc.contributor.authorEibach, Daniel
dc.contributor.authorMordmüller, Benjamin
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.contributor.authorNiendorf, Sandra
dc.contributor.authorAdegnika, Ayola Akim
dc.date.accessioned2022-02-01T09:21:14Z
dc.date.available2022-02-01T09:21:14Z
dc.date.issued2021-03-24none
dc.identifier.other10.3390/v13040545
dc.identifier.urihttp://edoc.rki.de/176904/9308
dc.description.abstractEnteric viruses are the leading cause of diarrhea in children globally. Identifying viral agents and understanding their genetic diversity could help to develop effective preventive measures. This study aimed to determine the detection rate and genetic diversity of four enteric viruses in Gabonese children aged below five years. Stool samples from children <5 years with (n = 177) and without (n = 67) diarrhea were collected from April 2018 to November 2019. Norovirus, astrovirus, sapovirus, and aichivirus A were identified using PCR techniques followed by sequencing and phylogenetic analyses. At least one viral agent was identified in 23.2% and 14.9% of the symptomatic and asymptomatic participants, respectively. Norovirus (14.7%) and astrovirus (7.3%) were the most prevalent in children with diarrhea, whereas in the healthy group norovirus (9%) followed by the first reported aichivirus A in Gabon (6%) were predominant. The predominant norovirus genogroup was GII, consisting mostly of genotype GII.P31-GII.4 Sydney. Phylogenetic analysis of the 3CD region of the aichivirus A genome revealed the presence of two genotypes (A and C) in the study cohort. Astrovirus and sapovirus showed a high diversity, with five different astrovirus genotypes and four sapovirus genotypes, respectively. Our findings give new insights into the circulation and genetic diversity of enteric viruses in Gabonese children.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectenteric viruseseng
dc.subjectchildreneng
dc.subjectphylogenetic analysiseng
dc.subjectdiarrheaeng
dc.subjectGaboneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleGenetic Diversity of Enteric Viruses in Children under Five Years Old in Gabonnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9308-5
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirusesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/1999-4915/13/4/545none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume13none
local.edoc.container-issue4none
local.edoc.container-year2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage15none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

Show simple item record