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2021-11-13Zeitschriftenartikel
Identification of Oocyst-Driven Toxoplasma gondii Infections in Humans and Animals through Stage-Specific Serology—Current Status and Future Perspectives
dc.contributor.authorGarcía, Gema Álvarez
dc.contributor.authorDavidson, Rebecca
dc.contributor.authorJokelainen, Pikka
dc.contributor.authorKlevar, Siv
dc.contributor.authorSpano, Furio
dc.contributor.authorSeeber, Frank
dc.date.accessioned2022-02-02T15:18:19Z
dc.date.available2022-02-02T15:18:19Z
dc.date.issued2021-11-13none
dc.identifier.other10.3390/microorganisms9112346
dc.identifier.urihttp://edoc.rki.de/176904/9358
dc.description.abstractThe apicomplexan zoonotic parasite Toxoplasma gondii has three infective stages: sporozoites in sporulated oocysts, which are shed in unsporulated form into the environment by infected felids; tissue cysts containing bradyzoites, and fast replicating tachyzoites that are responsible for acute toxoplasmosis. The contribution of oocysts to infections in both humans and animals is understudied despite being highly relevant. Only a few diagnostic antigens have been described to be capable of discriminating which parasite stage has caused an infection. Here we provide an extensive overview of the antigens and serological assays used to detect oocyst-driven infections in humans and animals according to the literature. In addition, we critically discuss the possibility to exploit the increasing knowledge of the T. gondii genome and the various ‘omics datasets available, by applying predictive algorithms, for the identification of new oocyst-specific proteins for diagnostic purposes. Finally, we propose a workflow for how such antigens and assays based on them should be evaluated to ensure reproducible and robust results.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectantigen predictioneng
dc.subjectoocyst-specific antigenseng
dc.subjectstage-specific serologyeng
dc.subjecttoxoplasmosiseng
dc.subjectsource attributioneng
dc.subjectsurfaceomeeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleIdentification of Oocyst-Driven Toxoplasma gondii Infections in Humans and Animals through Stage-Specific Serology—Current Status and Future Perspectivesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9358-7
dc.type.versionpublishedVersionnone
local.edoc.container-titleMicroorganismsnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/2076-2607/9/11/2346none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume9none
local.edoc.container-issue11none
local.edoc.container-year2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage25none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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