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2021-06-22Zeitschriftenartikel
Health‐related quality of life of children born to childhood cancer survivors in Germany
dc.contributor.authorBalcerek, Magdalena
dc.contributor.authorSommerhäuser, Greta
dc.contributor.authorSchilling, Ralph
dc.contributor.authorHölling, Heike
dc.contributor.authorKlco‐Brosius, Stephanie
dc.contributor.authorBorgmann‐Staudt, Anja
dc.date.accessioned2022-02-11T12:09:03Z
dc.date.available2022-02-11T12:09:03Z
dc.date.issued2021-06-22none
dc.identifier.other10.1002/pon.5752
dc.identifier.urihttp://edoc.rki.de/176904/9402
dc.description.abstractObjective: Rising childhood cancer survival rates have increased the importance of health-related quality of life (HRQL) assessment. While survivors show comparable HRQL to peers, concerns that cancer treatment could impact the health of prospective children were reported. No previous publications address HRQL of childhood cancer survivor offspring. Methods: We assessed survivor offspring HRQL using the parental KINDL questionnaire. Matched-pair analysis was conducted with data from the general population (KiGGS study) using age, gender and education (1:1, n = 1206 cases). Multivariate analyses were conducted to detect the influence of parental diagnose and treatment on offspring HRQL. Results: Overall, within KINDL dimensions, survivors reported comparable to higher HRQL for their children than the general population. Survivor parents reported significantly (p < 0.001) higher psychological (86.7% vs. 83.0%, Cohen's d = 0.3) and self-esteem (79.1% vs. 73.3%, Cohen's d = 0.5) well-being scores for younger children (3–6-year-olds). As time since diagnosis increased, parents reported higher well-being scores. Accordingly, recently diagnosed survivors reported significantly lower psychological well-being scores (p = 0.28; OR = 0.457; 95% CI = 0.228–0.918) for their children. With increasing age, average HRQL scores decreased in both cohorts; yet, this drop was less pronounced for survivor offspring. The biggest difference between age groups (7–10- vs. 14–17-year-olds) was found for school-specific well-being (6.2-point drop in survivor offspring vs. 18.2-point drop in KiGGS offspring). Conclusion: Comparable to higher parentally assessed HRQL was reported for survivor offspring compared to peers. These findings are reassuring and consistent with self-reported HRQL in childhood cancer survivors. Type of parental cancer diagnosis and treatment showed no negative impact on offspring HRQL.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectchildhood cancereng
dc.subjecthealth‐related quality of lifeeng
dc.subjectoffspringeng
dc.subjectoncologyeng
dc.subjectsurvivorseng
dc.subjectwell-beingeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHealth‐related quality of life of children born to childhood cancer survivors in Germanynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9402-1
dc.type.versionpublishedVersionnone
local.edoc.container-titlePsycho-Oncologynone
local.edoc.container-issn1099-1611none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/doi/10.1002/pon.5752none
local.edoc.container-publisher-nameWiley-Blackwellnone
local.edoc.container-volume30none
local.edoc.container-issue11none
local.edoc.container-year2021none
local.edoc.container-firstpage1866none
local.edoc.container-lastpage1875none
dc.description.versionPeer Reviewednone

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