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2021-07-20Zeitschriftenartikel
The effect of influenza and pneumococcal vaccination in the elderly on health service utilisation and costs: a claims data-based cohort study
dc.contributor.authorStorch, Josephine
dc.contributor.authorFleischmann‑Struzek, Carolin
dc.contributor.authorRose, Norman
dc.contributor.authorLehmann, Thomas
dc.contributor.authorMikolajetz, Anna
dc.contributor.authorMaddela, Srikanth
dc.contributor.authorPletz, Mathias W.
dc.contributor.authorForstner, Christina
dc.contributor.authorWichmann, Ole
dc.contributor.authorNeufeind, Julia
dc.contributor.authorVogel, Monique
dc.contributor.authorReinhart, Konrad
dc.contributor.authorVollmar, Horst Christian
dc.contributor.authorFreytag, Antje
dc.contributor.authorthe Vaccination 60+ Study Group
dc.date.accessioned2022-02-16T09:31:23Z
dc.date.available2022-02-16T09:31:23Z
dc.date.issued2021-07-20none
dc.identifier.other10.1007/s10198-021-01343-8
dc.identifier.urihttp://edoc.rki.de/176904/9426
dc.description.abstractBackground: To date, cost-effectiveness of influenza and pneumococcal vaccinations was assumed in several health economic modelling studies, but confirmation by real-world data is sparse. The aim of this study is to assess the effects on health care utilisation and costs in the elderly using real-world data on both, outpatient and inpatient care. Methods: Retrospective community-based cohort study with 138,877 individuals aged ≥ 60 years, insured in a large health insurance fund in Thuringia (Germany). We assessed health care utilisation and costs due to influenza- or pneumococcal-associated diseases, respiratory infections, and sepsis in 2015 and 2016. Individuals were classified into four groups according to their vaccination status from 2008 to 2016 (none, both, or either only influenza or pneumococcal vaccination). Inverse probability weighting based on 236 pre-treatment covariates was used to adjust for potential indication and healthy vaccinee bias. Results: Influenza vaccination appeared as cost-saving in 2016, with lower disease-related health care costs of − €178.87 [95% CI − €240.03;− €117.17] per individual (2015: − €50.02 [95% CI − €115.48;€15.44]). Cost-savings mainly resulted from hospital inpatient care, whereas higher costs occurred for outpatient care. Overall cost savings of pneumococcal vaccination were not statistically significant in both years, but disease-related outpatient care costs were lower in pneumococci-vaccinated individuals in 2015 [− €9.43; 95% CI − €17.56;− €1.30] and 2016 [− €12.93; 95% CI − €25.37;− €0.48]. Although we used complex adjustment, residual bias cannot be completely ruled out. Conclusion: Influenza and pneumococcal vaccination in the elderly can be cost-saving in selective seasons and health care divisions. As cost effects vary, interpretation of findings is partly challenging.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectClaims dataeng
dc.subjectReal-world dataeng
dc.subjectInfluenza vaccinationeng
dc.subjectPneumococcal vaccinationeng
dc.subjectElderlyeng
dc.subjectCosteng
dc.subjectHealth care utilisationeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe effect of influenza and pneumococcal vaccination in the elderly on health service utilisation and costs: a claims data-based cohort studynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9426-9
dc.type.versionpublishedVersionnone
local.edoc.container-titleThe European Journal of Health Economicsnone
local.edoc.container-issn1618-7601none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://link.springer.com/article/10.1007%2Fs10198-021-01343-8none
local.edoc.container-publisher-nameSpringer Science+Business Medianone
local.edoc.container-volume22none
local.edoc.container-year2021none
dc.description.versionPeer Reviewednone

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