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2021-11-11Zeitschriftenartikel
Viral Myocarditis—From Pathophysiology to Treatment
dc.contributor.authorSchultheiss, Heinz-Peter
dc.contributor.authorBaumeier, Christian
dc.contributor.authorAleshcheva, Ganna
dc.contributor.authorBock, Claus-Thomas
dc.contributor.authorEscher, Felicitas
dc.date.accessioned2022-03-14T11:25:37Z
dc.date.available2022-03-14T11:25:37Z
dc.date.issued2021-11-11none
dc.identifier.other10.3390/jcm10225240
dc.identifier.urihttp://edoc.rki.de/176904/9495
dc.description.abstractThe diagnosis of acute and chronic myocarditis remains a challenge for clinicians. Characterization of this disease has been hampered by its diverse etiologies and heterogeneous clinical presentations. Most cases of myocarditis are caused by infectious agents. Despite successful research in the last few years, the pathophysiology of viral myocarditis and its sequelae leading to severe heart failure with a poor prognosis is not fully understood and represents a significant public health issue globally. Most likely, at a certain point, besides viral persistence, several etiological types merge into a common pathogenic autoimmune process leading to chronic inflammation and tissue remodeling, ultimately resulting in the clinical phenotype of dilated cardiomyopathy. Understanding the underlying molecular mechanisms is necessary to assess the prognosis of patients and is fundamental to appropriate specific and personalized therapeutic strategies. To reach this clinical prerequisite, there is the need for advanced diagnostic tools, including an endomyocardial biopsy and guidelines to optimize the management of this disease. The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has currently led to the worst pandemic in a century and has awakened a special sensitivity throughout the world to viral infections. This work aims to summarize the pathophysiology of viral myocarditis, advanced diagnostic methods and the current state of treatment options.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectviral myocarditiseng
dc.subjectautoimmunityeng
dc.subjectdilated cardiomyopathyeng
dc.subjectpathophysiologyeng
dc.subjectendomyocardial biopsyeng
dc.subjecttherapeutic approacheng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleViral Myocarditis—From Pathophysiology to Treatmentnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9495-5
dc.type.versionpublishedVersionnone
local.edoc.container-titleJournal of Clinical Medicinenone
local.edoc.container-issn2077-0383none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/2077-0383/10/22/5240none
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume10none
local.edoc.container-issue22none
local.edoc.container-year2021none
dc.description.versionPeer Reviewednone

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