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2022-03-16Zeitschriftenartikel
Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load
dc.contributor.authorZhao, Lele
dc.contributor.authorWymant, Chris
dc.contributor.authorBlanquart, François
dc.contributor.authorGolubchik, Tanya
dc.contributor.authorGall, Astrid
dc.contributor.authorBakker, Margreet
dc.contributor.authorBezemer, Daniela
dc.contributor.authorHall, Matthew
dc.contributor.authorHoe Ong, Swee
dc.contributor.authorAlbert, Jan
dc.contributor.authorBannert, Norbert
dc.contributor.authorFellay, Jacques
dc.contributor.authorGrabowski, M. Kate
dc.contributor.authorGunsenheimer-Bartmeyer, Barbara
dc.contributor.authorGünthard, Huldrych F.
dc.contributor.authorKivelä, Pia
dc.contributor.authorKouyos, Roger D.
dc.contributor.authorLaeyendecker, Oliver
dc.contributor.authorMeyer, Laurence
dc.contributor.authorPorter, Kholoud
dc.contributor.authorvan Sighem, Ard
dc.contributor.authorvan der Valk, Marc
dc.contributor.authorBerkhout, Ben
dc.contributor.authorKellam, Paul
dc.contributor.authorCornelissen, Marion
dc.contributor.authorReiss, Peter
dc.contributor.authorFraser, Christophe
dc.contributor.authorFerretti, Luca
dc.contributor.authoron behalf of the BEEHIVE Collaboration
dc.date.accessioned2022-06-01T06:08:36Z
dc.date.available2022-06-01T06:08:36Z
dc.date.issued2022-03-16none
dc.identifier.other10.1093/ve/veac022
dc.identifier.urihttp://edoc.rki.de/176904/9771
dc.description.abstractSet-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising selection, with a typical optimum for the virus between 104 and 105 copies of viral RNA per ml. Here we aimed to detect transmission fitness differences between viruses from individuals with different SPVLs directly from phylogenetic trees inferred from whole-genome sequences. We used the local branching index (LBI) as a proxy for transmission fitness. We found that LBI is more sensitive to differences in infectiousness than to differences in the duration of the infectious state. By analysing subtype-B samples from the Bridging the Evolution and Epidemiology of HIV in Europe project, we inferred a significant positive relationship between SPVL and LBI up to approximately 105 copies/ml, with some evidence for a peak around this value of SPVL. This is evidence of selection against low values of SPVL in HIV-1 subtype-B strains, likely related to lower infectiousness, and perhaps a peak in the transmission fitness in the expected range of SPVL. The less prominent signatures of selection against higher SPVL could be explained by an inherent limit of the method or the deployment of antiretroviral therapy.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectHIV-1eng
dc.subjectbetween-host evolutioneng
dc.subjecttansmission fitnesseng
dc.subjectset-point viral loadeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePhylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral loadnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9771-2
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirus Evolutionnone
local.edoc.container-issn2057-1577none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://academic.oup.com/ve/article/8/1/veac022/6549258?login=truenone
local.edoc.container-publisher-nameOxford University Pressnone
local.edoc.container-volume8none
local.edoc.container-issue1none
local.edoc.container-year2022none
dc.description.versionPeer Reviewednone

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