Show simple item record

2022-04-05Zeitschriftenartikel
The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease
dc.contributor.authorZschüntzsch, Jana
dc.contributor.authorMeyer, Stefanie
dc.contributor.authorShahriyari, Mina
dc.contributor.authorKummer, Karsten
dc.contributor.authorSchmidt, Matthias
dc.contributor.authorKummer, Susann
dc.contributor.authorTiburcy, Malte
dc.date.accessioned2022-06-14T11:58:28Z
dc.date.available2022-06-14T11:58:28Z
dc.date.issued2022-04-05none
dc.identifier.other10.3390/cells11071233
dc.identifier.urihttp://edoc.rki.de/176904/9813
dc.description.abstractMany neuromuscular disease entities possess a significant disease burden and therapeutic options remain limited. Innovative human preclinical models may help to uncover relevant disease mechanisms and enhance the translation of therapeutic findings to strengthen neuromuscular disease precision medicine. By concentrating on idiopathic inflammatory muscle disorders, we summarize the recent evolution of the novel in vitro models to study disease mechanisms and therapeutic strategies. A particular focus is laid on the integration and simulation of multicellular interactions of muscle tissue in disease phenotypes in vitro. Finally, the requirements of a neuromuscular disease drug development workflow are discussed with a particular emphasis on cell sources, co-culture systems (including organoids), functionality, and throughput.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectmyositiseng
dc.subjectorganoideng
dc.subjecttissue engineeringeng
dc.subjectdrug screeningeng
dc.subjectvascularizationeng
dc.subjectco-cultureeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Diseasenone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9813-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleCellsnone
local.edoc.container-issn2073-4409none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/2073-4409/11/7/1233/htmnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume11none
local.edoc.container-issue7none
local.edoc.container-year2022none
dc.description.versionPeer Reviewednone

Show simple item record