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2022-04-07Zeitschriftenartikel
HIV pre-exposure prophylaxis was associated with no impact on sexually transmitted infection prevalence in a high-prevalence population of predominantly men who have sex with men, Germany, 2018 to 2019
dc.contributor.authorStreeck, Hendrik
dc.contributor.authorJansen, Klaus
dc.contributor.authorCrowell, Trevor A.
dc.contributor.authorEsber, Allahna
dc.contributor.authorJessen, Heiko K.
dc.contributor.authorCordes, Christiane
dc.contributor.authorScholten, Stefan
dc.contributor.authorSchneeweiss, Stephan
dc.contributor.authorBrockmeyer, Norbert
dc.contributor.authorSpinner, Christoph D.
dc.contributor.authorBickel, Markus
dc.contributor.authorEsser, Stefan
dc.contributor.authorHartikainen, Jukka
dc.contributor.authorStoehr, Albrecht
dc.contributor.authorLehmann, Clara
dc.contributor.authorMarcus, Ulrich
dc.contributor.authorVehreschild, Jörg Janne
dc.contributor.authorKnorr, Alexandra
dc.contributor.authorBrillen, Anna-Lena
dc.contributor.authorTiemann, Carsten
dc.contributor.authorRobb, Merlin L.
dc.contributor.authorMichael, Nelson L.
dc.date.accessioned2022-06-20T11:26:59Z
dc.date.available2022-06-20T11:26:59Z
dc.date.issued2022-04-07none
dc.identifier.other10.2807/1560-7917.ES.2022.27.14.2100591
dc.identifier.urihttp://edoc.rki.de/176904/9832
dc.description.abstractIntroduction: Despite increased use of pre-exposure prophylaxis (PrEP) in Germany, HIV infection rates are not declining and little is known about how this prevention method affects the prevalence of sexually transmitted infections (STI) among men who have sex with men (MSM). Aim: We studied, in a large multicentre cohort, STI point prevalence, co-infection rates, anatomical location and influence of PrEP. Methods: The BRAHMS study was a prospective cohort study conducted at 10 sites in seven major German cities that enrolled MSM reporting increased sexual risk behaviour. At screening visits, MSM were tested for Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Treponema pallidum (TP), and given a behavioural questionnaire. With binomial regression, we estimated prevalence ratios (PR) and 95% confidence intervals (CI) for the association of PrEP and STI. Results: We screened 1,043 MSM in 2018 and 2019, with 53.0% currently using PrEP. At screening, 370 participants (35.5%) had an STI. The most common pathogen was MG in 198 (19.0%) participants, followed by CT (n = 133; 12.8%), NG (n = 105; 10.1%) and TP (n = 37; 3.5%). Among the 370 participants with at least one STI, 14.6% (n = 54) reported STI-related symptoms. Infection prevalence was highest at anorectal site (13.4% MG, 6.5% NG, 10.2% CT). PrEP use was not statistically significant in adjusted models for STI (PR: 1.10; 95% CI: 0.91–1.32), NG/CT, only NG or only CT. Conclusions: Prevalence of asymptomatic STI was high, and PrEP use did not influence STI prevalence in MSM eligible for PrEP according to national guidelines.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHIV pre-exposure prophylaxis was associated with no impact on sexually transmitted infection prevalence in a high-prevalence population of predominantly men who have sex with men, Germany, 2018 to 2019none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9832-3
dc.type.versionpublishedVersionnone
local.edoc.container-titleEurosurveillancenone
local.edoc.container-issn1560-7917none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.14.2100591#abstract_contentnone
local.edoc.container-publisher-nameEuropean Centre for Disease Prevention and Controlnone
local.edoc.container-volume27none
local.edoc.container-issue14none
local.edoc.container-year2022none
dc.description.versionPeer Reviewednone

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