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2014-01-10Zeitschriftenartikel DOI: 10.1002/emmm.201303133
Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6
dc.contributor.authorBielaszewska, Martina
dc.contributor.authorSchiller, Roswitha
dc.contributor.authorLammers, Lydia
dc.contributor.authorBauwens, Andreas
dc.contributor.authorFruth, Angelika
dc.contributor.authorMiddendorf, Barbara
dc.contributor.authorSchmidt, Alexander
dc.contributor.authorTarr, Phillip I.
dc.contributor.authorDobrindt, Ulrich
dc.contributor.authorKarch, Helge
dc.contributor.authorMellmann, Alexander
dc.date.accessioned2018-05-07T17:31:33Z
dc.date.available2018-05-07T17:31:33Z
dc.date.created2014-03-07
dc.date.issued2014-01-10none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/resyModAfEFwo/PDF/29KqO0ZyKvhVM.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1830
dc.description.abstractExtraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non-pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin-producing E. coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and uropathogenic E. coli but also cause diarrhea and urinary tract infections. These organisms are phylogenetically positioned between members of an intestinal pathogenic group (STEC) and extraintestinal pathogenic E. coli. STEC O2:H6 is, therefore, a ‘heteropathogen,’ and the first such hybrid virulent E. coli identified. The phylogeny of these E. coli and the repertoire of virulence traits they possess compel consideration of an alternate view of pathogen emergence, whereby one pathogroup of E. coli undergoes phased metamorphosis into another. By understanding the evolutionary mechanisms of bacterial pathogens, rational strategies for counteracting their detrimental effects on humans can be developed.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectheteropathogenicityeng
dc.subjectphased metamorphosiseng
dc.subjectphylogenyeng
dc.subjectShiga toxin-producing Escherichia colieng
dc.subjecturopathogenic Escherichia colieng
dc.subject.ddc610 Medizin
dc.titleHeteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10035649
dc.identifier.doi10.1002/emmm.201303133
dc.identifier.doihttp://dx.doi.org/10.25646/1755
local.edoc.container-titleEMBO Molecular Medicine
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://onlinelibrary.wiley.com/doi/10.1002/emmm.201303133/
local.edoc.container-publisher-nameWiley
local.edoc.container-volume6
local.edoc.container-issue3
local.edoc.container-year2014

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