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2014-01-02Zeitschriftenartikel DOI: 10.1371/journal.ppat.1003844
Inflammation Fuels Colicin Ib-Dependent Competition of Salmonella Serovar Typhimurium and E. coli in Enterobacterial Blooms
dc.contributor.authorNedialkova, Lubov Petkova
dc.contributor.authorDenzler, Rémy
dc.contributor.authorKoeppel, Martin B.
dc.contributor.authorDiehl, Manuel
dc.contributor.authorRing, Diana
dc.contributor.authorWille, Thorsten
dc.contributor.authorGerlach, Roman
dc.contributor.authorStecher, Bärbel
dc.date.accessioned2018-05-07T17:32:30Z
dc.date.available2018-05-07T17:32:30Z
dc.date.created2014-03-12
dc.date.issued2014-01-02none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re89Pp5tE7MAc/PDF/238mYbsR4KCa6.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1835
dc.description.abstractThe host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae (“inflammation-inflicted blooms”). Here, we investigated competition of the human pathogenic Salmonella enterica serovar Typhimurium strain SL1344 (S. Tm) and commensal E. coli in inflammation-inflicted blooms. S. Tm produces colicin Ib (ColIb), which is a narrow-spectrum protein toxin active against related Enterobacteriaceae. Production of ColIb conferred a competitive advantage to S. Tm over sensitive E. coli strains in the inflamed gut. In contrast, an avirulent S. Tm mutant strain defective in triggering gut inflammation did not benefit from ColIb. Expression of ColIb (cib) is regulated by iron limitation and the SOS response. CirA, the cognate outer membrane receptor of ColIb on colicin-sensitive E. coli, is induced upon iron limitation. We demonstrate that growth in inflammation-induced blooms favours expression of both S. Tm ColIb and the receptor CirA, thereby fuelling ColIb dependent competition of S. Tm and commensal E. coli in the gut. In conclusion, this study uncovers a so-far unappreciated role of inflammation-inflicted blooms as an environment favouring ColIb-dependent competition of pathogenic and commensal representatives of the Enterobacteriaceae family.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectAnimalseng
dc.subjectMiceeng
dc.subjectIron/metabolismeng
dc.subjectSalmonella typhimurium/geneticseng
dc.subjectColicins/geneticseng
dc.subjectColicins/metabolismeng
dc.subjectEscherichia coli/metabolismeng
dc.subjectHumaneng
dc.subjectIntestines/microbiologyeng
dc.subjectSOS Response (Genetics)/physiologyeng
dc.subjectSalmonella Infections/geneticseng
dc.subjectSalmonella Infections/metabolismeng
dc.subjectSalmonella typhimurium/metabolismeng
dc.subject.ddc610 Medizin
dc.titleInflammation Fuels Colicin Ib-Dependent Competition of Salmonella Serovar Typhimurium and E. coli in Enterobacterial Blooms
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10035759
dc.identifier.doi10.1371/journal.ppat.1003844
dc.identifier.doihttp://dx.doi.org/10.25646/1760
local.edoc.container-titlePLoS Pathogens
local.edoc.container-textNedialkova LP, Denzler R, Koeppel MB, Diehl M, Ring D, et al. (2014) Inflammation Fuels Colicin Ib-Dependent Competition of Salmonella Serovar Typhimurium and E. coli in Enterobacterial Blooms. PLoS Pathog 10(1): e1003844.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003844
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume10
local.edoc.container-issue1
local.edoc.container-year2014

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