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2016-01-14Zeitschriftenartikel DOI: 10.1186/s12985-016-0514-6
Molecular epidemiology of hepatitis D virus circulating in Southwestern Nigeria
dc.contributor.authorOpaleye, Oluyinka Oladele
dc.contributor.authorJaphet, Oluwatoyin Margaret
dc.contributor.authorAdewumi, Olubusuyi Moses
dc.contributor.authorOmoruyi, Ewean Chukwuma
dc.contributor.authorAkanbi, Olusola Anuoluwapo
dc.contributor.authorOluremi, Adeolu Sunday
dc.contributor.authorWang, Bo
dc.contributor.authorTong, Hoang van
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.contributor.authorBock, Thomas
dc.date.accessioned2018-05-07T19:03:02Z
dc.date.available2018-05-07T19:03:02Z
dc.date.created2016-05-18
dc.date.issued2016-01-14none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reyJtW7Vum3c/PDF/24jPj3DfPDgA2.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2324
dc.description.abstractBackground: Hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major public health problems in sub-Saharan Africa. Whereas it is known that HBV infection is endemic in Nigeria, there is only little data about HDV prevalence available. Here, we assessed the HDV seroprevalence and determined the HDV and HBV genotypes distribution among HBsAg positive individuals in Southwestern Nigeria. Methods: This cross-sectional study involved 188 serum samples from HBsAg positive outpatients recruited at four tertiary hospitals in Southwestern Nigeria. Anti-HDV antibodies were detected by ELISA while HDV-RNA was detected by RT-PCR. Sequencing followed by phylogenetic analyses and HBV genotype-specific PCR were used to characterize HDV and HBV genotypes, respectively. Results: Out of 188 HBsAg positive serum samples, 17 (9 %) showed detectable HDV-RNA. Anti-HDV antibodies test was possible from 103 samples and were observed in 4.9 % (5/103) patients. There was no significant difference in HDV prevalence between four main cities across the country. 64.7 % of HDV-RNA positive samples were from males and 35.3 % from females (P eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHepatitis D viruseng
dc.subjectHDV genotypeeng
dc.subjectMolecular epidemiologyeng
dc.subjectHBV infectioneng
dc.subjectNigeriaeng
dc.subject.ddc610 Medizin
dc.titleMolecular epidemiology of hepatitis D virus circulating in Southwestern Nigeria
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10045201
dc.identifier.doi10.1186/s12985-016-0514-6
dc.identifier.doihttp://dx.doi.org/10.25646/2249
local.edoc.container-titleVirology Journal
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://virologyj.biomedcentral.com/articles/10.1186/s12985-016-0514-6
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume13
local.edoc.container-issue61
local.edoc.container-year2016

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