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2016-06-20Zeitschriftenartikel DOI: 10.1371/journal.pone.0157733
Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women
dc.contributor.authorMerz, Benedikt
dc.contributor.authorNöthlings, Ute
dc.contributor.authorWahl, Simone
dc.contributor.authorHaftenberger, Marjolein
dc.contributor.authorSchienkiewitz, Anja
dc.contributor.authorAdamski, Jerzy
dc.contributor.authorSuhre, Karsten
dc.contributor.authorWang-Sattler, Rui
dc.contributor.authorGrallert, Harald
dc.contributor.authorThorand, Barbara
dc.contributor.authorPischon, Tobias
dc.contributor.authorBachlechner, Ursula
dc.contributor.authorFloegel, Anna
dc.contributor.authorPeters, Annette
dc.contributor.authorBoeing, Heiner
dc.date.accessioned2018-05-07T19:06:29Z
dc.date.available2018-05-07T19:06:29Z
dc.date.created2016-06-22
dc.date.issued2016-06-20none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re6bWk1fbrpA/PDF/22aj4H3K65JR6.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2343
dc.description.abstractObjective: Our study aims to identify metabolic markers associated with either a gain in abdominal (measured by waist circumference) or peripheral (measured by hip circumference) body fat mass. Methods: Data of 4 126 weight-gaining adults (18–75 years) from three population-based, prospective German cohort studies (EPIC, KORA, DEGS) were analysed regarding a waist-gaining (WG) or hip-gaining phenotype (HG). The phenotypes were obtained by calculating the differences of annual changes in waist minus hip circumference. The difference was displayed for all cohorts. The highest 10% of this difference were defined as WG whereas the lowest 10% were defined as HG. A total of 121 concordant metabolite measurements were conducted using Biocrates AbsoluteIDQ® kits in EPIC and KORA. Sex-specific associations with metabolite concentration as independent and phenotype as the dependent variable adjusted for confounders were calculated. The Benjamini-Hochberg method was used to correct for multiple testing. Results: Across studies both sexes gained on average more waist than hip circumference. We could identify 12 metabolites as being associated with the WG (n = 8) or HG (n = 4) in men, but none were significant after correction for multiple testing; 45 metabolites were associated with the WG (n = 41) or HG (n = 4) in women. For WG, n = 21 metabolites remained significant after correction for multiple testing. Respective odds ratios (OR) ranged from 0.66 to 0.73 for tryptophan, the diacyl-phosphatidylcholines (PC) C32:3, C36:0, C38:0, C38:1, C42:2, C42:5, the acyl-alkyl-PCs C32:2, C34:0, C36:0, C36:1, C36:2, C38:0, C38:2, C40:1, C40:2, C40:5, C40:6, 42:2, C42:3 and lyso-PC C17:0. Conclusion: Both weight-gaining men and women showed a clear tendency to gain more abdominal than peripheral fat. Gain of abdominal fat seems to be related to an initial metabolic state reflected by low concentrations of specific metabolites, at least in women. Thus, higher levels of specific PCs may play a protective role in gaining waist circumference.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
dc.subject.ddc610 Medizin
dc.titleSpecific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10045607
dc.identifier.doi10.1371/journal.pone.0157733
dc.identifier.doihttp://dx.doi.org/10.25646/2268
local.edoc.container-titlePLoS ONE
local.edoc.container-textMerz B, Nöthlings U, Wahl S, Haftenberger M, Schienkiewitz A, Adamski J, et al. (2016) Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women. PLoS ONE 11(6): e0157733.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157733
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume11
local.edoc.container-issue6
local.edoc.container-year2016

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