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2016-08-06Zeitschriftenartikel DOI: 10.1016/j.ebiom.2016.07.039
Hepatitis E Virus Mutations: Functional and Clinical Relevance
dc.contributor.authorTong, Hoang van
dc.contributor.authorHoan, Nghiem Xuan
dc.contributor.authorWang, Bo
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorBock, Thomas
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2018-05-07T19:24:30Z
dc.date.available2018-05-07T19:24:30Z
dc.date.created2016-10-06
dc.date.issued2016-08-06none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re1kHyXPnTnkY/PDF/238f8i2mAT2mA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2441
dc.description.abstractHepatitis E virus (HEV) infection is a major cause of acute hepatitis and affects more than 20 million individuals, with three million symptomatic cases and 56,000 recognized HEV-related deaths worldwide. HEV is endemic in developing countries and is gaining importance in developed countries, due to increased number of autochthone cases. Although HEV replication is controlled by the host immune system, viral factors (especially specific viral genotypes and mutants) can modulate HEV replication, infection and pathogenesis. Limited knowledge exists on the contribution of HEV genome variants towards pathogenesis, susceptibility and to therapeutic response. Nonsynonymous substitutions can modulate viral proteins structurally and thus dysregulate virus-host interactions. This review aims to compile knowledge and discuss recent advances on the casual role of HEV heterogeneity and its variants on viral morphogenesis, pathogenesis, clinical outcome and antiviral resistance.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHepatitis E viruseng
dc.subjectHEV infectioneng
dc.subjectHEV mutationeng
dc.subjectHEV variabilityeng
dc.subjectHEV treatment failureeng
dc.subjectHEV replicationeng
dc.subject.ddc610 Medizin
dc.titleHepatitis E Virus Mutations: Functional and Clinical Relevance
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10047189
dc.identifier.doi10.1016/j.ebiom.2016.07.039
dc.identifier.doihttp://dx.doi.org/10.25646/2366
local.edoc.container-titleEBioMedicine
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S2352396416303498
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume11
local.edoc.container-year2016

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