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2011-05-06Zeitschriftenartikel DOI: 10.1089/vbz.2010.0236
Rodents as Sentinels for the Prevalence of Tick-Borne Encephalitis Virus
dc.contributor.authorAchazi, Katharina
dc.contributor.authorRuzek, Daniel
dc.contributor.authorMantke, Oliver Donoso
dc.contributor.authorSchlegel, Mathias
dc.contributor.authorAli, Hanan Sheikh
dc.contributor.authorWenk, Mathias
dc.contributor.authorSchmidt-Chanasit, Jonas
dc.contributor.authorOhlmeyer, Lutz
dc.contributor.authorRühe, Ferdinand
dc.contributor.authorVor, Torsten
dc.contributor.authorKiffner, Christian
dc.contributor.authorKallies, René
dc.contributor.authorUlrich, Rainer
dc.contributor.authorNiedrig, Matthias
dc.date.accessioned2018-05-07T14:36:02Z
dc.date.available2018-05-07T14:36:02Z
dc.date.created2011-05-16
dc.date.issued2011-05-06none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reOxRMXKD1l1A/PDF/21gRN5a0EwQ16.pdf
dc.identifier.urihttp://edoc.rki.de/176904/873
dc.description.abstractIntroduction: Tick-borne encephalitis virus (TBEV) causes one of the most important flavivirus infections of the central nervous system, affecting humans in Europe and Asia. It is mainly transmitted by the bite of an infected tick and circulates among them and their vertebrate hosts. Until now, TBE risk analysis in Germany has been based on the incidence of human cases. Because of an increasing vaccination rate, this approach might be misleading, especially in regions of low virus circulation. Method: To test the suitability of rodents as a surrogate marker for virus spread, laboratory-bred Microtus arvalis voles were experimentally infected with TBEV and analyzed over a period of 100 days by real-time (RT)–quantitative polymerase chain reaction. Further, the prevalence of TBEV in rodents trapped in Brandenburg, a rural federal state in northeastern Germany with autochthonous TBE cases, was determined and compared with that in rodents from German TBE risk areas as well as TBE nonrisk areas. Results: In experimentally infected M. arvalis voles, TBEV was detectable in different organs for at least 3 months and in blood for 1 month. Ten percent of all rodents investigated were positive for TBEV. However, in TBE risk areas, the infection rate was higher compared with that of areas with only single human cases or of nonrisk areas. TBEV was detected in six rodent species: Apodemus agrarius, Apodemus flavicollis, Apodemus sylvaticus, Microtus agrestis, Microtus arvalis, and Myodes glareolus. M. glareolus showed a high infection rate in all areas investigated. Discussion and Conclusion: The infection experiments proved that TBEV can be reliably detected in infected M. arvalis voles. These voles developed a persistent TBE infection without clinical symptoms. Further, the study showed that rodents, especially M. glareolus, are promising sentinels particularly in areas of low TBEV circulation.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjectAnimalseng
dc.subjectPrevalenceeng
dc.subjectSentinel Surveillanceeng
dc.subjectGenetic Variationeng
dc.subjectEncephalitis Viruseseng
dc.subjectRNA Viral/isolation & purificationeng
dc.subjectTick-Borne/isolation & purificationeng
dc.subjectEncephalitis Viruses Tick-Borne/geneticseng
dc.subjectEncephalitis Tick-Borne/epidemiologyeng
dc.subjectEncephalitis Tick-Borne/veterinaryeng
dc.subjectNorway/epidemiologyeng
dc.subjectNucleic Acid Conformationeng
dc.subjectRodent Diseases/epidemiologyeng
dc.subjectRodentiaeng
dc.subject.ddc610 Medizin
dc.titleRodents as Sentinels for the Prevalence of Tick-Borne Encephalitis Virus
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10014202
dc.identifier.doi10.1089/vbz.2010.0236
dc.identifier.doihttp://dx.doi.org/10.25646/798
local.edoc.container-titleVector-Borne and Zoonotic Diseases
local.edoc.container-textAchazi, K., RůŽek, D., Donoso-Mantke, O., Schlegel, M., Ali, H.S., Wenk, M., Schmidt-Chanasit, J., Ohlmeyer, L., Rühe, F., Vor, T., Kiffner, C., Kallies, R., Ulrich, R.G., Niedrig, M. Rodents as sentinels for the prevalence of tick-borne encephalitis virus (2011) Vector-Borne and Zoonotic Diseases, 11 (6), pp. 641-647.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.liebertonline.com/doi/abs/10.1089/vbz.2010.0236
local.edoc.container-publisher-nameMary Ann Liebert, Inc.
local.edoc.container-volume11
local.edoc.container-issue6
local.edoc.container-year2011

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