- edoc-Server Home
- Browsing by Author
Browsing by Author "McConville, Malcolm J."
Now showing items 1-6 of 6
-
2014-07-17ZeitschriftenartikelBCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei Oppenheim, Rebecca D.; Creek, Darren J.; Macrae, James I.; Modrzynska, Katarzyna K.; Pino, Paco; Limenitakis, Julien; Polonais, Valerie; Seeber, Frank; Barrett, Michael P.; Billker, Oliver; McConville, Malcolm J.; Soldati-Favre, DominiqueWhile the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical ...
-
2021-08-25ZeitschriftenartikelCoordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii Fairweather, Stephen J.; Rajendran, Esther; Blume, Martin; Javed, Kiran; Steinhöfel, Birte; McConville, Malcolm J.; Kirk, Kiaran; Bröer, Stefan; van Dooren, Giel G.Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We previously identified a large family of apicomplexan-specific plasma membrane-localized amino ...
-
2020-06-02ZeitschriftenartikelLeishmania Encodes a Bacterium-like 2,4-Dienoyl-Coenzyme A Reductase That Is Required for Fatty Acid β-Oxidation and Intracellular Parasite Survival Semini, Geo; Paape, Daniel; Blume, Martin; Sernee, M. Fleur; Peres-Alonso, Diego; Calvignac-Spencer, Sébastien; Döllinger, Jörg; Jehle, Stefan; Saunders, Eleanor; McConville, Malcolm J.; Aebischer, ToniLeishmaniaspp. are protozoan parasites that cause a spectrum of im-portant diseases in humans. These parasites develop as extracellular promastigotesin the digestive tract of their insect vectors and as obligate intracellular ...
-
2021-11-22ZeitschriftenartikelThe Redox Homeostasis of Skeletal Muscle Cells Regulates Stage Differentiation of Toxoplasma gondii Rahman, Taibur; Swierzy, Izabela J.; Downie, Bryan; Salinas, Gabriela; Blume, Martin; McConville, Malcolm J.; Lüder, Carsten G. K.Toxoplasma gondii is an obligatory intracellular parasite that causes persistent infections in birds and mammals including ~30% of the world’s human population. Differentiation from proliferative and metabolically active ...
-
2019-02-11ZeitschriftenartikelThe tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family Parker, Kathryn E. R.; Fairweather, Stephen J.; Rajendran, Esther; Blume, Martin; McConville, Malcolm J.; Bröer, Stefan; Kirk, Kiaran; van Dooren, Giel G.Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their host cells, either through direct uptake or degradation of host proteins. Here, we describe a family of plasma membrane-localized ...
-
2021-12-21ZeitschriftenartikelToxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway Henkel, Stephanie; Frohnecke, Nora; Maus, Deborah; McConville, Malcolm J.; Laue, Michael; Blume, Martin; Seeber, FrankApicomplexan parasites, such as Toxoplasma gondii, are unusual in that each cell contains a single apicoplast, a plastid- like organelle that compartmentalizes enzymes involved in the essential 2C-methyl-D-erythritol ...