Browsing by Author "Müller, Marcel A."

Now showing items 1-9 of 9

2016-05-13Zeitschriftenartikel

An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus

Horie, Masayuki; Kobayashi, Yuki; Honda, Tomoyuki; Fujino, Kan; Akasaka, Takumi; Kohl, Claudia; Wibbelt, Gudrun; Mühldorfer, Kristin; Kurth, Andreas; Müller, Marcel A.; Corman, Victor M.; Gillich, Nadine; Suzuki, Yoshiyuki; Schwemmle, Martin; Tomonaga, Keizo

Endogenous bornavirus-like L (EBLL) elements are inheritable sequences derived from ancient bornavirus L genes that encode a viral RNA-dependent RNA polymerase (RdRp) in many eukaryotic genomes. Here, we demonstrate that ...
2012-12-06Zeitschriftenartikel

Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections

Corman, V. M.; Müller, Marcel A.; Costabel, U.; Timm, J.; Binger, T.; Meyer, B.; Kreher, Petra; Lattwein, Erik; Eschbach-Bludau, M.; Nitsche, Andreas; Bleicker, T.; Landt, Olfert; Schweiger, Brunhilde; Drexler, Jan Felix; Osterhaus, A. D.; Haagmans, B. L.; Dittmer, U.; Bonin, F.; Wolff, Thorsten; Drosten, Christian

We present a rigorously validated and highly sensitive confirmatory real-time RT-PCR assay (1A assay) that can be used in combination with the previously reported upE assay. Two additional RT-PCR assays for sequencing are ...
2013-02-21Zeitschriftenartikel

Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012

Buchholz, Udo; Müller, Marcel A.; Nitsche, Andreas; Sanewski, A.; Wevering, N.; Bauer-Balci, T.; Bonin, F.; Drosten, Christian; Schweiger, Brunhilde; Wolff, Thorsten; Muth, D.; Meyer, B.; Buda, Silke; Krause, Gérard; Schaade, Lars; Haas, Walter

On 24 October 2012, a patient with acute respiratory distress syndrome of unknown origin and symptom onset on 5 October was transferred from Qatar to a specialist lung clinic in Germany. Late diagnosis on 20 November of ...
2007-09-01Zeitschriftenartikel

Coronavirus Antibodies in African Bat Species

Müller, Marcel A.; Paweska, Janusz T.; Leman, Patricia A.; Drosten, Christian; Grywna, Klaus; Kemp, Alan; Braack, Leo; Sonnenberg, Karen; Niedrig, Matthias; Swanepoel, Robert

Asian bats have been identified as potential reservoir hosts of coronaviruses associated with severe acute respiratory syndrome (SARS-CoV). We detected antibody reactive with SARS-CoV antigen in 47 (6.7%) of 705 bat serum ...
2021-10-08Zeitschriftenartikel

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

Loyal, Lucie; Braun, Julian; Henze, Larissa; Kruse, Beate; Dingeldey, Manuela; Reimer, Ulf; Kern, Florian; Schwarz, Tatjana; Mangold, Maike; Unger, Clara; Dörfler, Friederike; Kadler, Shirin; Rosowski, Jennifer; Gürcan, Kübrah; Uyar-Aydin, Zehra; Frentsch, Marco; Kurth, Florian; Schnatbbaum, Karsten; Eckey, Maren; Hippenstiel, Stefan; Hocke, Andreas; Müller, Marcel A.; Sawitzki, Birgit; Miltenyi, Stefan; Paul, Friedemann; Mall, Marcus A.; Wenschuh, Holger; Voigt, Sebastian; Drosten, Christian; Lauster, Roland; Lachman, Nils; Sander, Leif-Erik; Corman, Victor M.; Röhmel, Jobst; Meyer-Arndt, Lil; Thiel, Andreas; Giesecke-Thiel, Claudia

INTRODUCTION The clinical manifestations of COVID-19 vary from asymptomatic infection to respiratory failure. Severe disease courses are primarily associated with advanced age, immune dysfunctions, and comorbidities. ...
2021-09-07Zeitschriftenartikel

Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

Schroeder, Simon; Christin, Mache; Kleine-Weber, Hannah; Corman, Victor M.; Muth, Doreen; Richter, Anja; Fatykhova, Diana; Memish, Ziad A.; Stanifer, Megan L.; Boulant, Steeve; Gultom, Mitra; Dijkman, Ronald; Eggeling, Stephan; Hocke, Andreas; Hippenstiel, Stefan; Thiel, Volker; Pöhlmann, Stefan; Wolff, Thorsten; Müller, Marcel A.; Drosten, Christian

Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels across the Middle East and Africa. Virus-induced pneumonia in humans results from animal contact, with a potential for limited onward ...
2010-01-15Zeitschriftenartikel

Human Coronavirus NL63 Open Reading Frame 3 encodes a virion-incorporated N-glycosylated membrane protein

Müller, Marcel A.; Hoek, Lia van der; Voss, Daniel; Bader, Oliver; Lehmann, Dörte; Schulz, Axel R.; Kallies, Stephan; Suliman, Tasnim; Fielding, Burtram C; Drosten, Christian; Niedrig, Matthias

Background: Human pathogenic coronavirus NL63 (hCoV-NL63) is a group 1 (alpha) coronavirus commonly associated with respiratory tract infections. In addition to known non-structural and structural proteins all coronaviruses ...
2013-06-11Zeitschriftenartikel

Provenance and Geographic Spread of St. Louis Encephalitis Virus

Kopp, Anne; Gillespie, Thomas R.; Hobelsberger, Daniel; Estrada, Alejandro; Harper, James M.; Miller, Richard A.; Eckerle, Isabella; Müller, Marcel A.; Podsiadlowski, Lars; Leendertz, Fabian; Drosten, Christian; Junglen, Sandra

St. Louis encephalitis virus (SLEV) is the prototypic mosquito-borne flavivirus in the Americas. Birds are its primary vertebrate hosts, but amplification in certain mammals has also been suggested. The place and time of ...
2022-11-16Zeitschriftenartikel

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

Niemeyer, Daniela; Stenzel, Saskia; Veith, Talitha; Schroeder, Simon; Friedmann, Kirstin; Weege, Friederike; Trimpert, Jakob; Heinze, Julian; Richter, Anja; Jansen, Jenny; Emanuel, Jackson; Kazmierski, Julia; Pott, Fabian; Jeworowski, Lara M.; Olmer, Ruth; Jaboreck, Mark-Christian; Tenner, Beate; Papies, Jan; Walper, Felix; Schmidt, Marie L.; Heinemann, Nicolas; Möncke-Buchner, Elisabeth; Baumgardt, Morris; Hoffmann, Karen; Widera, Marek; Thao, Tran Thi Nhu; Balázs, Anita; Schulze, Jessica; Mache, Christin; Jones, Terry Carleton; Morkel, Markus; Ciesek, Sandra; Hanitsch, Leif G.; Mall, Markus A.; Hocke, Andreas C.; Thiel, Volker; Osterrieder, Klaus; Wolff, Thorsten; Martin, Ulrich; Corman, Victor M.; Müller, Marcel A.; Goffinet, Christine; Drosten, Christian

Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. ...