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Browsing by Author "Fleige, Carola"
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2016-11-28ZeitschriftenartikelDetection of a cfr(B) Variant in German Enterococcus faecium Clinical Isolates and the Impact on Linezolid Resistance in Enterococcus spp. Bender, Jennifer K.; Fleige, Carola; Klare, Ingo; Fiedler, Stefan; Mischnik, Alexander; Mutters, Nico T.; Dingle, Kate E.; Werner, GuidoThe National Reference Centre for Staphylococci and Enterococci in Germany has received an increasing number of clinical linezolid-resistant E. faecium isolates in recent years. Five isolates harbored a cfr(B) variant ...
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2021-07-27ZeitschriftenartikelDetermination of a Tentative Epidemiological Cut-Off Value (ECOFF) for Dalbavancin and Enterococcus faecium Weber, Robert E.; Fleige, Carola; Layer, Franziska; Neumann, Bernd; Kresken, Michael; Werner, GuidoDalbavancin is a lipoglycopeptide antibiotic that shows potent activity against Gram-positive bacteria. It circumvents vanB-type glycopeptide resistance mechanisms; however, data on the in vitro activity of dalbavancin for ...
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2020-12-29ZeitschriftenartikelExcellent performance of CHROMagarTM LIN-R to selectively screen for linezolid-resistant enterococci and staphylococci Layer, Franziska; Weber, Robert E.; Fleige, Carola; Strommenger, Birgit; Cuny, Christiane; Werner, GuidoThe increasing number of nosocomial pathogens with resistances against last resort antibiotics like linezolid leads to a pressing need for the reliable detection of these drug-resistant bacteria. National guidelines ...
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2011-03-31ZeitschriftenartikelIS element IS16 as a molecular screening tool to identify hospital-associated strains of Enterococcus faecium Werner, Guido; Fleige, Carola; Geringer, Uta; Schaik, Willem van; Klare, Ingo; Witte, WolfgangBackground: Hospital strains of Enterococcus faecium could be characterized and typed by various molecular methods (MLST, AFLP, MLVA) and allocated to a distinct clonal complex known as MLST CC17. However, these techniques ...
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2012-08-15ZeitschriftenartikelPerformance of three chromogenic VRE screening agars, two Etest® vancomycin protocols, and different microdilution methods in detecting vanB genotype Enterococcus faecium with varying vancomycin MICs Klare, Ingo; Fleige, Carola; Geringer, Uta; Witte, Wolfgang; Werner, GuidoFrequencies of vanB-type Enterococcus faecium increased in Europe during the last years. VanB enterococci show various levels of vancomycin MICs even below the susceptible breakpoint challenging a reliable diagnostics. The ...
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2016-02-23ZeitschriftenartikelPopulation structure and acquisition of the vanB resistance determinant in German clinical isolates of Enterococcus faecium ST192 Bender, Jennifer K.; Kalmbach, Alexander; Fleige, Carola; Klare, Ingo; Fuchs, Stephan; Werner, GuidoIn the context of the global action plan to reduce the dissemination of antibiotic resistances it is of utmost importance to understand the population structure of resistant endemic bacterial lineages and to elucidate how ...
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2019-12-23ZeitschriftenartikelValidating a screening agar for linezolidresistant enterococci Werner, Guido; Fleige, Carola; Klare, Ingo; Weber, Robert E.; Bender, Jennifer K.Background: Linezolid is an alternative treatment option for infections with multidrug-resistant Gram-positive bacteria including vancomycin-resistant enterococci. Some countries report an increasing number of isolates ...
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2012-05-30ZeitschriftenartikelVancomycin-resistant vanB-type Enterococcus faecium isolates expressing varying levels of vancomycin resistance and being highly prevalent among neonatal patients in a single ICU Werner, Guido; Klare, Ingo; Fleige, Carola; Geringer, Uta; Witte, Wolfgang; Just, Heinz-Michael; Ziegler, RenateBackground: Vancomycin-resistant isolates of E. faecalis and E. faecium are of special concern and patients at risk of acquiring a VRE colonization/infection include also intensively-cared neonates. We describe here an ...