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Auflistung nach Autor "Thomzig, Achim"
Anzeige der Publikationen 1-14 von 14
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2007-05-25ZeitschriftenartikelAccumulation of Pathological Prion Protein PrPSc in the Skin of Animals with Experimental and Natural Scrapie Thomzig, Achim; Schulz-Schaeffer, Walter; Wrede, Arne; Wemheuer, Wilhelm; Brenig, Bertram; Kratzel, Christine; Lemmer, Karin; Beekes, MichaelPrion infectivity and its molecular marker, the pathological prion protein PrPSc, accumulate in the central nervous system and often also in lymphoid tissue of animals or humans affected by transmissible spongiform ...
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2021-05-06ZeitschriftenartikelCorrection to: Transmissible α‑synuclein seeding activity in brain and stomach of patients with Parkinson’s disease Thomzig, Achim; Wagenführ, Katja; Pinder, Phillip; Joncic, Marion; Schulz-Schaeffer, Walter J.; Beekes, Michael
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2014-10-25ZeitschriftenartikelDecontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates Thomzig, Achim; Wagenführ, Katja; Daus, Martin L.; Joncic, Marion; Schulz-Schaeffer, Walter J.; Thanheiser, Marc; Mielke, Martin; Beekes, Michael
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2008-09-29ZeitschriftenartikelFaecal shedding, alimentary clearance and intestinal spread of prions in hamsters fed with scrapie Krüger, Dominique; Thomzig, Achim; Lenz, Gudrun; Kampf, Kristin; McBride, Patricia; Beekes, MichaelShedding of prions via faeces may be involved in the transmission of contagious prion diseases. Here, we fed hamsters 10mg of 263K scrapie brain homogenate and examined the faecal excretion of disease-associated prion ...
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2009-10-28ZeitschriftenartikelFast broad-range disinfection of bacteria, fungi, viruses and prions Beekes, Michael; Lemmer, Karin; Thomzig, Achim; Joncic, Marion; Tintelnot, Kathrin; Mielke, MartinEffective disinfectants are of key importance for the safe handling and reprocessing of surgical instruments. We tested whether new formulations containing SDS, NaOH and 1-propanol (n-propanol) are simultaneously active ...
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2013-04-22ZeitschriftenartikelFoodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates Holznagel, Edgar; Yutzy, Barbara; Schulz-Schaeffer, Walter; Kruip, Carina; Hahmann, Uwe; Bierke, Pär; Torres, Juan-Maria; Kim, Yong-Sun; Thomzig, Achim; Beekes, Michael; Hunsmann, Gerhard; Löwer, JohannesRisk for human exposure to bovine spongiform encephalopathy (BSE)–inducing agent was estimated in a nonhuman primate model. To determine attack rates, incubation times, and molecular signatures, we orally exposed 18 macaques ...
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2014-07-30ZeitschriftenartikelIs there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles? Beekes, Michael; Thomzig, Achim; Schulz-Schaeffer, Walter J.; Burger, ReinhardThe misfolding and aggregation of endogenous proteins in the central nervous system is a neuropathological hallmark of Alzheimer’s disease (AD), Parkinson’s disease (PD), as well as prion diseases. A molecular mechanism ...
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2011-04-01ZeitschriftenartikelPresence and seeding activity of pathological prion protein (PrP(TSE)) in skeletal muscles of white-tailed deer infected with chronic wasting disease. Daus, Martin L.; Breyer, Johanna; Wagenführ, Katja; Wemheuer, Wiebke M.; Thomzig, Achim; Schulz-Schaeffer, Walter; Beekes, MichaelChronic wasting disease (CWD) is a contagious, rapidly spreading transmissible spongiform encephalopathy (TSE), or prion disease, occurring in cervids such as white tailed-deer (WTD), mule deer or elk in North America. ...
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2022-02-09ZeitschriftenartikelPrimary glia cells from bank vole propagate multiple rodent-adapted scrapie prions Schwenke, Karla A.; Wälzlein, Joo-Hee; Bauer, Agnieszka; Thomzig, Achim; Beekes, MichaelSince the beginning prion research has been largely dependent on animal models for deciphering the disease, drug development or prion detection and quantification. Thereby, ethical as well as cost and labour-saving aspects ...
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2011-05-27ZeitschriftenartikelQuantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. Pritzkow, Sandra; Wagenführ, Katja; Daus, Martin L.; Boerner, Susann; Lemmer, Karin; Thomzig, Achim; Mielke, Martin; Beekes, MichaelPrions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which ...
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2007-05-09ZeitschriftenartikelScrapie Agent (Strain 263K) Can Transmit Disease via the Oral Route after Persistence in Soil over Years Seidel, Bjoern; Thomzig, Achim; Buschmann, Anne; Groschup, Martin H.; Peters, Rainer; Beekes, Michael; Terytze, KonstantinThe persistence of infectious biomolecules in soil constitutes a substantial challenge. This holds particularly true with respect to prions, the causative agents of transmissible spongiform encephalopathies (TSEs) such as ...
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2021-04-16ZeitschriftenartikelStability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein Langeveld, Jan P.M.; Balkema-Buschmann, Anne; Becher, Dieter; Thomzig, Achim; Nonno, Romolo; Olivier, Andréoletti; Davidse, Aart; Di Bari, Michele A.; Pirisinu, Laura; Agrimi, Umberto; Groschup, Martin H.; Beekes, Michael; Shih, JasonThe unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrPSc, aberrant depositions of the host’s cellular prion protein (PrPC). Successive ...
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2013-03-11ZeitschriftenartikelTowards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays Boerner, Susann; Wagenführ, Katja; Daus, Martin L.; Thomzig, Achim; Beekes, MichaelLaboratory animals have long since been used extensively in bioassays for prions in order to quantify, usually in terms of median infective doses [ID50], how infectious these pathogens are in vivo. The identification of ...
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2021-04-24ZeitschriftenartikelTransmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson’s disease Thomzig, Achim; Wagenführ, Katja; Pinder, Phillip; Joncic, Marion; Schulz-Schaeffer, Walter J.; Beekes, MichaelCerebral deposition of abnormally aggregated α-synuclein (αSyn) is a neuropathological hallmark of Parkinson’s disease (PD). PD-associated αSyn (αSynPD) aggregates can act as proteinaceous nuclei (“seeds”) able of ...